Download PDF
Synfacts 2011(7): 0695-0695  
DOI: 10.1055/s-0030-1260489
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of (±)-Alopecuridine

Contributor(s): Steven V. Ley, Catherine F. Carter
X.-M. Zhang, Y.-Q. Tu*, F.-M. Zhang, H. Shao, X. Meng
Lanzhou University, P. R. of China
Further Information

Publication History

Publication Date:
17 June 2011 (online)

   Permissions and Reprints

Significance

(±)-Alopecuridine A is a Lycopodium alkaloid that is a biological precursor for the significantly cytotoxic (±)-sieboline A. The first total synthesis is achieved here in 13 steps, followed by the conversion into (±)-sieboline A that validates the biogenetic pathway.