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Synfacts 2011(6): 0641-0641
DOI: 10.1055/s-0030-1260441
DOI: 10.1055/s-0030-1260441
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag
Stuttgart ˙ New York
Asymmetric Addition of Boronic Acids to N-Benzylnicotinate Salts
C. Nadeau*, S. Aly, K. Belyk
Merck Frosst Centre for Therapeutic Research, Kirkland, Canada and Merck Research Laboratories, Rahway, USA
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
19. Mai 2011 (online)
Significance
Reported is the synthesis of chiral dihydropyridine derivatives via the rhodium-catalyzed highly enantioselective asymmetric addition of both aryl- and alkenylboronic acids to N-benzylnicotinate salts. An efficient application of this methodology to the preparation of synthetically useful N-Boc piperidine acid salts was also reported.