A mild and straightforward strategy for the synthesis of 4-(fluoroalkyl)oxazolidin-2-ones
via one-pot addition-intramolecular N-cyclization of allyl
carbamates with fluoroalkyl iodides is presented. The reaction proceeded
in moderate to good yield through regiocontrol and an increase in
the reactivity of the ambident nucleophiles by the use of alkali
metallic reagents.
allyl carbamates - 4-(fluoroalkyl)oxazolidin-2-ones - addition-intramolecular N-cyclization - alkali
metallic reagents