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Synthesis 2011(22): 3627-3634
DOI: 10.1055/s-0030-1260239
DOI: 10.1055/s-0030-1260239
PAPER
© Georg Thieme Verlag
Stuttgart ˙ New York
One-Pot Addition-Intramolecular N-Cyclization of Carbamates Mediated by Alkali Metallic Reagents as an Approach to 4-(Fluoroalkyl)oxazolidin-2-ones
Further Information
Publication History
Received
23 July 2011
Publication Date:
26 September 2011 (online)


Abstract
A mild and straightforward strategy for the synthesis of 4-(fluoroalkyl)oxazolidin-2-ones via one-pot addition-intramolecular N-cyclization of allyl carbamates with fluoroalkyl iodides is presented. The reaction proceeded in moderate to good yield through regiocontrol and an increase in the reactivity of the ambident nucleophiles by the use of alkali metallic reagents.
Key words
allyl carbamates - 4-(fluoroalkyl)oxazolidin-2-ones - addition-intramolecular N-cyclization - alkali metallic reagents
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