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Synthesis 2011(19): 3115-3122
DOI: 10.1055/s-0030-1260197
DOI: 10.1055/s-0030-1260197
PAPER
© Georg Thieme Verlag
Stuttgart ˙ New York
Efficient and Original Microwave-Assisted Suzuki-Miyaura Cross-Coupling Reaction in the 4H-Pyrido[1,2-a]pyrimidin-4-one Series
Further Information
Publication History
Received
18 May 2011
Publication Date:
01 September 2011 (online)


Abstract
An efficient synthesis of new series of various 3-aryl, 3-heteroaryl, and 3-styryl-4H-pyrido[1,2-a]pyrimidin-4-ones by palladium-catalyzed Suzuki-Miyaura cross-coupling reactions using microwave irradiation is described. The coupling process is tolerant of electron-poor, electron-rich, and bulky boronic acid derivatives, and leads to the desired products in good yields.
Key words
cross-coupling - 4H-pyrido[1,2-a]pyrimidin-4-one - palladium - Suzuki reaction - arylation