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Synthesis 2011(11): 1759-1770
DOI: 10.1055/s-0030-1260033
DOI: 10.1055/s-0030-1260033
PAPER
© Georg Thieme Verlag
Stuttgart ˙ New York
Synthesis and Biological Evaluation of Modified 2-Deoxystreptamine Dimers
Further Information
Received
3 November 2010
Publication Date:
06 May 2011 (online)
Publication History
Publication Date:
06 May 2011 (online)
![](https://www.thieme-connect.de/media/synthesis/201111/lookinside/thumbnails/10.1055-s-0030-1260033-1.jpg)
Abstract
Aminoglycosides are powerful antibiotics, but the emergence of resistant bacterial strains has prompted the search for analogues with better pharmacological profiles. The synthesis of 2-deoxystreptamine (2-DOS) dimers linked by polyamines and analogues based on furylcarbopeptoid skeletons is described. Potent and selective ligands for bacterial 16S rRNA were identified using microarray techniques by determining the affinity of these derivatives toward bacterial and human ribosomal RNAs.
Key words
antibiotics - 2-deoxystreptamine dimers - microarray - ribosomal RNA - solid-phase synthesis
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