Synthesis of a New Pyrido[3,2-b]carbazole as an Ellipticine-Makaluvamine Hybrid

Sébastien Bouclé; Jérôme Guillard

doi:10.1055/s-0030-1260015

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Synthesis 2011(10): 1616-1620
DOI: 10.1055/s-0030-1260015

PAPER

Synthesis of a New Pyrido[3,2-b]carbazole as an Ellipticine-Makaluvamine Hybrid

Sébastien Bouclé, Jérôme Guillard*
UMR CNRS 6239 Génétique Immunothérapie Chimie et Cancer UFR des Sciences Pharmaceutiques, Université François Rabelais de Tours, 31 avenue Monge, 37200 Tours, France
Fax: +33(2)47367229; e-Mail: guillard@univ-tours.fr;

Further Information

Publication History

Received 8 February 2011
Publication Date:
19 April 2011 (online)

Abstract
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Abstract

The first synthesis of pyrido[3,2-b]carbazole as an ellipticine-makaluvamine hybrid in 13 steps and 2% overall yield from commercially available 2,5-dimethoxyaniline is described.

Key words

heterocycles - Heck reaction - ring closure - homogeneous catalysis - polycycles

References

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