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Synlett 2011(9): 1333-1334  
DOI: 10.1055/s-0030-1259951
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© Georg Thieme Verlag Stuttgart ˙ New York

Diethyl Tartrate

Christine Weiss*
Department of Chemistry, Organic and Bioorganic Chemistry, ­Bielefeld University, Universitätsstr. 25, 33615 Bielefeld, Germany
e-Mail: c.weiss@uni-bielefeld.de;
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Publication History

Publication Date:
18 April 2011 (online)

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Introduction

Diethyl tartrate (DET) is a clear colorless slightly viscous liquid. It is the diethyl ester of tartaric acid, which is one of the most important α-hydroxy acids and originates from the chiral pool. l-DET (CAS: 87-91-2) and d-DET (CAS: 13811-71-7) are abundant and commercially available at low and moderate cost, respectively.

Diethyl tartrate has a wide range of applications in organic synthesis including precursors for chiral catalysts [¹] and auxiliaries. [²] The desired stereoselectivity is tunable upon use of the corresponding enantiomer of diethyl tartrate. It was efficiently applied as a scaffold for the enantioselective synthesis of biomolecules. [³] In addition, it has been employed as a chiral resolving reagent. [4]

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