Chemoenzymatic Synthesis of
Idesolide from Benzoic Acid

David R. Adams; Christian Aichinger; Jonathan Collins; Uwe Rinner; Tomas Hudlicky

doi:10.1055/s-0030-1259694

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Synlett 2011(5): 725-729
DOI: 10.1055/s-0030-1259694

LETTER

Chemoenzymatic Synthesis of Idesolide from Benzoic Acid

David R. Adams^a, Christian Aichinger^b, Jonathan Collins^a, Uwe Rinner^b, Tomas Hudlicky*^a
^a Chemistry Department and Centre for Biotechnology, Brock University, 500 Glenridge Avenue, St. Catharines, Ontario L2S 3A1, Canada
Fax: +1(905)9844841; e-Mail: thudlicky@brocku.ca;
^b Institute of Organic Chemistry, University of Vienna, Währinger Str. 38, 1090 Vienna, Austria

Further Information

Publication History

Received 20 January 2011
Publication Date:
25 February 2011 (online)

Abstract
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Abstract

Idesolide was synthesized in five steps from benzoic acid by base-catalyzed dimerization of hydroxy keto ester, obtained from diol, the product of the whole-cell fermentation of benzoic acid with R. eutrophus B9.

Key words

idesolide - hydroxy keto ester - diol - whole-cell fermentation - benzoic acid

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