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Synlett 2011(4): 547-550
DOI: 10.1055/s-0030-1259514
DOI: 10.1055/s-0030-1259514
LETTER
© Georg Thieme Verlag
Stuttgart ˙ New York
Total Synthesis of Amphilectane-Type Diterpenoid (±)-7-Isocyanoamphilecta-11(20),15-diene
Further Information
Received
8 December 2010
Publication Date:
27 January 2011 (online)
Publication History
Publication Date:
27 January 2011 (online)
Abstract
The total synthesis of amphilectane-type diterpenoid ()-7-isocyanoamphilecta-11(20),15-diene, isolated from the tropical marine sponge Cymbastela hooperi, was achieved. The synthesis involves construction of a cis-decalin ring by an intramolecular Diels-Alder reaction and construction of an all-trans-perhydrophenalene ring by an intramolecular Michael reaction as the key steps.
Key words
total synthesis - 7-isocyanoamphilecta-11(20),15-diene - isocyanide - intramolecular Diels-Alder reaction - intramolecular Michael reaction
- Supporting Information for this article is available online:
- Supporting Information
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