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Synfacts 2011(3): 0304-0304  
DOI: 10.1055/s-0030-1259481
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Enantioselective Mannich-Type Three-Component Reaction

Contributor(s): Mark Lautens, Jane Panteleev
X. Xu, Y. Qian, L. Yang, W. Hu*
East China Normal University, Shanghai, P. R. of China
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Publikationsverlauf

Publikationsdatum:
16. Februar 2011 (online)

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Significance

In recent years, multicomponent as well as domino reactions have received considerable attention in light of their relevance to atom economy (see Book below). The authors report a multicomponent reaction involving the generation of a rhodium carbenoid and its reaction with aldim-ines under chiral Brønsted acid catalysis. The use of a transition metal as well as an an organocatalyst in situ is significant. This work follows the group’s earlier explorations of domino reactions involving diazo compounds (Angew. Chem. Int. Ed. 2010, 49, 2190).

Book: Multicomponent Reactions, J. Zhu, H. Bienaymé, Eds.; Wiley-VCH: Weinheim, 2005.