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Synfacts 2011(3): 0292-0292
DOI: 10.1055/s-0030-1259471
DOI: 10.1055/s-0030-1259471
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag
Stuttgart ˙ New York
Chromium-Catalyzed Enantioselective Alkynylation of Aldehydes
D. L. Usanov, H. Yamamoto*
The University of Chicago, USA
Further Information
Publication History
Publication Date:
16 February 2011 (online)
Significance
The preparation of enantiomerically pure propargyl alcohols is an important task since they are useful and versatile building blocks in organic synthesis. Herein, the authors describe the first example of an asymmetric chromium-catalyzed alkynylation of aldehydes 1 with 1-haloalkynes 2 towards chiral propargylic alcohols of type 3 in high yields and good to excellent enantioselectivities (up to 92% ee).