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Synfacts 2011(3): 0242-0242  
DOI: 10.1055/s-0030-1259402
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of Atorvastatin Lactone

Contributor(s): Philip Kocienski
P. Sawant, M. E. Maier*
Universität Tübingen, Germany
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Publication History

Publication Date:
16 February 2011 (online)

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Significance

The enantioselective iridium-­catalyzed transfer hydrogenative coupling of allyl acetate with an alcohol was used twice (A → B and C → D) in the early stages of a synthesis of atorvastatin lactone. A classical Paal-Knorr reaction was used to construct the pyrrole H.