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Synfacts 2011(1): 0013-0013
DOI: 10.1055/s-0030-1258979
DOI: 10.1055/s-0030-1258979
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag
Stuttgart ˙ New York
Synthesis of LY503430
B. Duthion, D. Gomez Pardo*, J. Cossy*
ESPCI ParisTech, France
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
21. Dezember 2010 (online)
![](https://www.thieme-connect.de/media/synfacts/201101/lookinside/thumbnails/10.1055-s-0030-1258979-1.jpg)
Significance
LY503430 is a neuroprotective agent that reduces brain damage caused by 6-hydroxydopamine or the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). It is a lead for the treatment of Parkinson’s and Alzheimer’s disease, depression and schizophrenia. For a kg-scale synthesis of LY503430 based on a classical resolution, see: N. A. Magnus et al. Org. Process Res. Dev. 2005, 9, 621.