Subscribe to RSS
Please copy the URL and add it into your RSS Feed Reader.
https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00000131.xml
Synfacts 2010(10): 1150-1150
DOI: 10.1055/s-0030-1258681
DOI: 10.1055/s-0030-1258681
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag
Stuttgart ˙ New York
Palladium(II)-Catalyzed Dicarboxylation of Chiral Allylic Alcohols
O. Hamed, P. M. Henry, D. P. Becker*
Loyola University Chicago, USA
Further Information
Publication History
Publication Date:
22 September 2010 (online)
Significance
The authors describe a method for the dicarboxylation of allylic alcohols to generate products bearing three contiguous stereogenic centers. The reaction proceeds at room temperature with up to 98% conservation of enantiomeric excess.