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Synfacts 2010(10): 1152-1152  
DOI: 10.1055/s-0030-1258654
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Stereoselective Synthesis of Cyclic Ethers

Contributor(s): Mark Lautens, David A. Candito
L. Liu, P. E. Floreancig*
University of Pittsburgh, USA
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Publication History

Publication Date:
22 September 2010 (online)

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Significance

Building upon previous work (L. Liu, P. E. Floreancig Angew. Chem. Int. Ed. 2010, 49, 3069) the authors address stereochemical issues in the intramolecular Prins-type cyclization for the synthesis of tertiary ethers. The authors put forth two simple models for under-standing the selectivity of the cyclization. It is anticipated that these models will find use in more complex substrates.