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Synthesis 2011(8): 1267-1278
DOI: 10.1055/s-0030-1258478
DOI: 10.1055/s-0030-1258478
PAPER
© Georg Thieme Verlag
Stuttgart ˙ New York
Synthesis of 3-Alkyl-4-(chloromethyl)-1-RSO2-1H-pyrrol-2(5H)-ones, Using a Sequential ATRC/[1,2]-Elimination, from 2,2-Dichloro-N-(2-chloroallyl)-N-RSO2-amides
Weitere Informationen
Publikationsverlauf
Received
17 December 2010
Publikationsdatum:
16. März 2011 (online)


Abstract
The preparation of 3-alkyl-4-(chloromethyl)-1-RSO2-1H-pyrrol-2(5H)-ones was efficiently accomplished through a [1,2]-elimination of γ-lactams derived from the copper(I)-catalysed ATRC of 2,2-dichloro-N-(2-chloroallyl)-N-RSO2-amides. The two reactions can be integrated into a sequential one-pot process.
Key words
copper - cyclization - elimination - lactams - radical reaction