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Synthesis 2011(8): 1255-1260
DOI: 10.1055/s-0030-1258477
DOI: 10.1055/s-0030-1258477
PAPER
© Georg Thieme Verlag
Stuttgart ˙ New York
Regioselective Preparation of Functionalized Isoxazoline Derivatives as Key Intermediates for the Synthesis of Selective N-Methyl-d-aspartate Receptor Antagonists
Further Information
Received
10 December 2010
Publication Date:
16 March 2011 (online)
Publication History
Publication Date:
16 March 2011 (online)
![](https://www.thieme-connect.de/media/synthesis/201108/lookinside/thumbnails/10.1055-s-0030-1258477-1.jpg)
Abstract
Two highly versatile isoxazoline derivatives, as key intermediates for the synthesis of differently functionalized subtype-selective N-methyl-d-aspartate receptor antagonists, were designed and synthesized. The synthetic strategy is based on an intramolecular nitrile oxide cycloaddition reaction which is a powerful method capable of controlling both the regio- and stereochemistry of the pericyclic reaction.
Key words
N-methyl-d-aspartate receptor antagonist - intramolecular nitrile oxide cycloaddition - regioselective - isoxazoline - amino acids
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