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Synthesis 2011(8): 1283-1289
DOI: 10.1055/s-0030-1258473
DOI: 10.1055/s-0030-1258473
PAPER
© Georg Thieme Verlag
Stuttgart ˙ New York
Improved Synthesis of Coumarins by Iron(III)-Catalyzed Cascade Reaction of Propiolic Acids and Phenols
Further Information
Received
31 January 2011
Publication Date:
10 March 2011 (online)
Publication History
Publication Date:
10 March 2011 (online)
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Abstract
The reaction of propiolic acids with phenols in the presence of FeCl3/AgOTf catalyst proceeded efficiently in a mixed solvent of trifluoroacetic acid and 1,2-dichloroethane, and provided coumarins in good to high yields. This iron-catalyzed reaction offers a much-improved synthesis of coumarins.
Key words
iron - hydroarylation - coumarins - propiolic acids - propynoic acids - phenols
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