Synthesis of a Series of Novel Thieno- and Benzothieno[3,2-d]pyrimidin-4(3H)-ones

Abstract

A series of novel thieno- and benzothieno[3,2-d]pyrimidin-4(3H)-ones is synthesised via condensation of 3-amino(benzo)thiophene-2-carboxylates with various lactams.

Key words

thieno[3,2-d]pyrimidin-4(3H)-ones - benzothieno[3,2-d]pyrimidin-4(3H)-ones - 3-aminothiophene-2-carboxylate - 3-amino benzothiophene-2-carboxylate

References

• 1 Migianu E. Kirsch G. Synthesis  2002,  1096 
• 2 Karkola S. Lilienkampf A. Wähälä K. ChemMedChem  2008,  3:  461 
• 3 Wähälä K, Lilienkampf A, Alho S, Huhtinen K, Johansson N, Koskimies P, and Vihko K. inventors;  WO2004110549.  ; Chem. Abstr. 2004, 142, 74590
• 4a Vilsmeier A. Haack A. Ber.  1927,  60:  119 
• 4b Arnold Z. Sorm F. Collect. Czech. Chem. Commun.  1958,  23:  452 
• 5 Hartmann H. Liebscher J. Synthesis  1984,  275 
• 6 Thomae D. Kirsch G. Seck P. Synthesis  2007,  1027 
• 7 Beck RJ. Yahner JA. J. Org. Chem.  1974,  39:  3440 
• 8a Torisawa Y. Nishi T. Minamikawa J.-i. Bioorg. Med. Chem. Lett.  2002,  12:  387 
• 8b Torisawa Y. Nishi T. Minamikawa J.-i. Bioorg. Med. Chem.  2003,  11:  2205 
• 9 Carpenter RD. Lam KS. Kurth MJ. J. Org. Chem.  2007,  72:  284