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Synthesis 2011(4): 563-570  
DOI: 10.1055/s-0030-1258417
PAPER
© Georg Thieme Verlag Stuttgart ˙ New York

Facile Multicomponent Synthesis of Novel 2,3-Dihydropyran Derivatives under Solvent-Free Conditions

Li Li, Qi Wu*, Bo-Kai Liu, Xian-Fu Lin*
Department of Chemistry, Zhejiang University, Hangzhou 310027, P. R. of China
Fax: +86(571)87952618; e-Mail: llc123@zju.edu.cn;
Further Information

Publication History

Received 10 November 2010
Publication Date:
21 January 2011 (online)

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Abstract

A series of new, substituted 2,3-dihydropyran derivatives were synthesized by one-pot, three-component reactions of aldehydes, 1,3-dicarbonyl derivatives, and vinyl ethers catalyzed by ethylenediamine diacetate (EDDA) under solvent-free conditions. This new, simple, and efficient, solvent-free, one-pot approach to the substituted 2,3-dihydropyran scaffold starting from simple substrates was found to take place directly.

Key words

multicomponent reaction - one-pot - 2,3-dihydropyran - solvent-free - EDDA

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