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Synthesis 2011(4): 635-641
DOI: 10.1055/s-0030-1258405
DOI: 10.1055/s-0030-1258405
PAPER
© Georg Thieme Verlag
Stuttgart ˙ New York
Thermal and Microwave-Assisted Rapid Syntheses of Substituted Imidazo[1,2-a]pyridines Under Solvent- and Catalyst-Free Conditions
Weitere Informationen
Publikationsverlauf
Received
15 November 2010
Publikationsdatum:
12. Januar 2011 (online)


Abstract
Thermal and microwave-assisted rapid syntheses of highly substituted imidazo[1,2-a]pyridine derivatives by reaction of aminopyridines and α-bromo-β-keto esters under solvent-free conditions are described. Reactions carried out under microwave irradiation give the highest yields of products in reaction times of less than two minutes.
Key words
aminopyridines - α-bromo-β-keto esters - imidazo[1,2-a]pyridines - microwave irradiation - solvent-free - thermal