Synthesis 2011(4): 635-641  
DOI: 10.1055/s-0030-1258405
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© Georg Thieme Verlag Stuttgart ˙ New York

Thermal and Microwave-Assisted Rapid Syntheses of Substituted Imidazo[1,2-a]pyridines Under Solvent- and Catalyst-Free Conditions

Kaushik C. Chunavala, Girdhar Joshi, Eringathodi Suresh, Subbarayappa Adimurthy*
Central Salt and Marine Chemicals Research Institute (CSIR), G. B. Marg, Bhavnagar 364 002, Gujarat, India
Fax: +91(278)2567562; e-Mail: sadimurthy@yahoo.com;
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Received 15 November 2010
Publikationsdatum:
12. Januar 2011 (online)

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Abstract

Thermal and microwave-assisted rapid syntheses of highly substituted imidazo[1,2-a]pyridine derivatives by reaction of aminopyridines and α-bromo-β-keto esters under solvent-free conditions are described. Reactions carried out under microwave irradiation give the highest yields of products in reaction times of less than two minutes.

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