Selective Halogenation at Position
3 of 5-Hydroxy-2,7-dimethylchromone and Related Compounds

Pia Königs; Björn Rinker; Gregor Schnakenburg; Martin Nieger; Siegfried R. Waldvogel

doi:10.1055/s-0030-1258404

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Synthesis 2011(4): 593-598
DOI: 10.1055/s-0030-1258404

PAPER

Selective Halogenation at Position 3 of 5-Hydroxy-2,7-dimethylchromone and Related Compounds

Pia Königs^a, Björn Rinker^a, Gregor Schnakenburg^b, Martin Nieger^c, Siegfried R. Waldvogel*^a,d
^a Kekulé Institute for Organic Chemistry and Biochemistry, University of Bonn, Gerhard-Domagk-Str.1, 53121 Bonn, Germany
^b Institute of Inorganic Chemistry, University of Bonn, Gerhard-Domagk-Str.1, 53121 Bonn, Germany
^c Laboratory of Inorganic Chemistry, Department of Chemistry, University of Helsinki, P.O. Box 55, 00014 Helsinki, Finland
^d Institute for Organic Chemistry, Johannes-Gutenberg University, Duesbergweg 10-14, 55128 Mainz, Germany
Fax: +49(6131)3926777; e-Mail: waldvogel@uni-mainz.de;

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Publikationsverlauf

Received 25 August 2010
Publikationsdatum:
11. Januar 2011 (online)

Abstract
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Abstract

The core moiety of several natural products referred in the literature as altechromone A can be selectively brominated or iodinated at position 3 despite the adjacent phenolic moiety. This method is extended to more elaborated 5-hydroxychromones exhibiting additional multiple bonds.

Key words

halogenation - heterocycles - chromones - iodination - bromination

Supporting Information

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