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Synthesis 2011(3): 480-484
DOI: 10.1055/s-0030-1258377
DOI: 10.1055/s-0030-1258377
PAPER
© Georg Thieme Verlag
Stuttgart ˙ New YorkNew Access to 5-Substituted 1,3-Benzothiazol-2(3H)-ones and Their N-Methyl Analogues by a Palladium Coupling Reaction
Weitere Informationen
Received
18 October 2010
Publikationsdatum:
20. Dezember 2010 (online)
Publikationsverlauf
Publikationsdatum:
20. Dezember 2010 (online)
Abstract
5-Substituted 1,3-benzothiazol-2(3H)-ones and their N-methyl analogues were readily prepared from the corresponding 5-bromo-1,3-benzothiazol-2(3H)-ones by means of Stille and Suzuki reactions. The compounds were substituted at the C-5 position with vinyl, acyl, or aryl groups optionally carrying electron-withdrawing or electron-donating substituents.
Key words
heterocycles - coupling - catalysis - benzothiazolones - Stille reaction
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