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Synthesis 2011(2): 229-234
DOI: 10.1055/s-0030-1258344
DOI: 10.1055/s-0030-1258344
PAPER
© Georg Thieme Verlag
Stuttgart ˙ New York
Synthesis of Chromeno[3,4-b]quinolines: Electrophilic Aromatic Substitution under Heck Conditions
Further Information
Received
15 September 2010
Publication Date:
26 November 2010 (online)
Publication History
Publication Date:
26 November 2010 (online)
![](https://www.thieme-connect.de/media/synthesis/201102/lookinside/thumbnails/10.1055-s-0030-1258344-1.jpg)
Abstract
The palladium-mediated intramolecular coupling reaction of 2-[(3-substituted-phenoxy)methyl]quinolines for preparing chromeno[3,4-b]quinolines was explored. The results of the cyclizations gave convincing evidence for an electrophilic aromatic substitution mechanism under standard Heck conditions.
Key words
palladium catalysis - Heck reaction - electrophilic aromatic substitution - chromenoquinoline - aryl-heteroaryl coupling
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