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DOI: 10.1055/s-0030-1258313
A Concise and Flexible Diastereoselective Approach to Heteroring-Fused Isoindolinones
Publication History
Publication Date:
25 October 2010 (online)
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Abstract
A variety of poly and diversely substituted isoindolinones fused with six-membered heterocyclic moieties has been readily assembled through a sequence involving metalation of N-chloroalkylated models, subsequent interception with appropriate electrophiles and ultimate intramolecular annulation reaction.
Key words
carbanions - fused-ring systems - lactams - metalation - cyclization
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References
Selected X-ray crystallographic data for 9j: Empirical formula: C19H19NO4; Mr = 325.35 g˙mol-¹; F(000) = 688; white crystal; D = 1.353 g˙cm-³; µ(Mo Kα) = 0.095; monoclinic; P21/n; a = 5.56820 (10) Å, b = 8.60050 (10) Å, c = 33.3710 (6) Å; α = 90.00, β = 91.8710 (10), γ = 90.00; V = 1597.26 (4) ų; Z = 4; T = 100 K. Further details of the X-ray structure data are available on request from the Cambridge Crystallographic Data Centre (CCDC 791641)