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Synthesis 2010(16): 2721-2724  
DOI: 10.1055/s-0030-1258150
PAPER
© Georg Thieme Verlag Stuttgart ˙ New York

One-Pot Double Suzuki Couplings of Dichloropyrimidines

Samantha C. Anderson, Scott T. Handy*
Department of Chemistry, Middle Tennessee State University, Murfreesboro, TN 37132, USA
Fax: +1(615)8985182; e-Mail: shandy@mtsu.edu;
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Publikationsverlauf

Received 17 February 2010
Publikationsdatum:
07. Juli 2010 (online)

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Abstract

An effective one-pot, regioselective double Suzuki coupling of 2,4-dichloropyrimidine has been developed, which enables the quick and efficient synthesis of diarylated pyrimidines. The choice of solvent proved critical to the success of this reaction sequence, with alcoholic solvent mixtures affording much greater reactivity and requiring correspondingly lower temperatures than the use of polar aprotic solvents.

Key words

pyrimidines - Suzuki coupling - regioselectivity - palladium-catalyzed - one-pot reaction

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