Synlett 2010(11): 1688-1690  
DOI: 10.1055/s-0030-1258095
LETTER
© Georg Thieme Verlag Stuttgart ˙ New York

Improved Palladium-Catalysed Synthesis of α-Benzyl-β-keto Esters

Nicholas J. Bennett*a, Anne Goldbyb, Rachel Pringlec
a Chemistry Department, AstraZeneca R&D Charnwood, Bakewell Road, Loughborough, LE11 5RH, UK
Fax: +44(1509)645571; e-Mail: Nicholas.bennett@astrazeneca.com;
b School of Chemistry, University of Nottingham, University Park, Nottingham, NG7 2RD, UK
c Department of Chemistry, Loughborough University, Loughborough, LE11 3TU, UK
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Publikationsverlauf

Received 28 January 2010
Publikationsdatum:
15. Juni 2010 (online)

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Abstract

This paper describes the development of an imporved protocol for the synthesis of α-benzyl-β-keto esters from aryl bromides via Heck reaction. The use of this protocol to synthesise a variety of diverse α-benzyl-β-keto esters for use in the preparation of new pharmaceutical agents is demonstrated.