Synlett 2010(11): 1669-1673  
DOI: 10.1055/s-0030-1258082
LETTER
© Georg Thieme Verlag Stuttgart ˙ New York

A Facile Synthesis of Novel Pyrrolidine Dendrimers by Terminal Group Modification through 1,3-Dipolar Cycloaddition Reaction

Perumal Rajakumar*, Sebastian Raja, Ayyavu Thirunarayanan
Department of Organic Chemistry, University of Madras, Guindy Campus, Chennai 600 025, India
Fax: +91(44)22300488; e-Mail: perumalrajakumar@gmail.com;
Further Information

Publication History

Received 30 March 2010
Publication Date:
11 June 2010 (online)

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Abstract

A series of novel dendrimers with pyrrolidine as surface group has been achieved in high yields by terminal-group modification on chalcone dendrimers through the application of 1,3-dipolar cycloaddition reaction. In 1,3-dipolar cycloaddition, azomethine ylides (AMY) with alkenes afforded five-membered N-methyl pyrrolidine. The formation of N-methyl pyrrolidine in the dendritic structure would be an important candidate in the field of biology and pharmacology.