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Synfacts 2010(9): 0996-0996
DOI: 10.1055/s-0030-1258007
DOI: 10.1055/s-0030-1258007
Synthesis of Heterocycles
© Georg Thieme Verlag
Stuttgart ˙ New York
Silver- and Iron-Catalyzed Synthesis of Substituted Thiazoles
X. Gao, Y.-m. Pan, M. Lin, L. Chen, Z.-p. Zhan*
Xiamen University, P. R. of China
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
23. August 2010 (online)
Significance
Reported is the synthesis of substituted thiazoles through the silver(I) triflate catalyzed reaction of propargyl alcohols with thioamides. Also reported is a one-pot synthesis of thiazoles through the iron(III) chloride catalyzed reaction of propargyl alcohols with amides followed by sulfurization effected by Lawesson’s reagent and then ring closure. Mechanisms for these reactions were proposed but no evidence was provided.