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Synfacts 2010(8): 0936-0936
DOI: 10.1055/s-0030-1257758
DOI: 10.1055/s-0030-1257758
Metal-Mediated Synthesis
© Georg Thieme Verlag
Stuttgart ˙ New York
Phosphorodiamidate-Directed Metalation of N-Heterocycles using Mg- and Zn-TMP
C. J. Rohbogner, S. Wirth, P. Knochel*
Ludwig-Maximilians-Universität München, Germany
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
22. Juli 2010 (online)
Significance
The strong metalation-directing power of the tetramethylphosphorodiamidate group has been used for achieving selective metalations on various N-heterocycles like pyridines, quinolines, and quinoxalines using TMP-derived bases. The resulting ortho-metalated species can be trapped with a wide range of electrophiles affording functionalized heteroaromatics in very good yields.