Very high quality clinical and translational research has been presented at the Digestive Disease Week (DDW) 2010 in New Orleans (1 – 5 May, New Orleans, Louisiana, USA). Here, a selection of the 16 best abstracts presented from the upper gastrointestinal field are briefly reviewed, with focus on Barrett’s esophagus and reflux-related diseases. In selecting the abstracts specific relevance has been given to the following three elements: the impact of studies on daily clinical practice; their contribution to the understanding of the natural history of diseases; and the translational potential to introduce new diagnostic tools.
References
1
Yousef F, Cardwell C, Cantwell M M. et al .
The incidence of esophageal cancer and high-grade dysplasia in Barrett’s esophagus: a systematic review and meta-analysis.
Am J Epidemiol.
2008;
168
237-249
2
Wani S B, Falk G W, Hall M, Wang A. et al .
Low risk of developing dysplasia and esophageal adenocarcinoma (EAC) in patients with non-dysplastic Barrett’s esophagus (BE): results from a large, multicenter, cohort study.
Gastroenterology.
2010;
138
S-63
3
Corley D A, Mehtani K, Zhao W. et al .
Barrett’s esophagus surveillance and risk of death from esophageal adenocarcinoma: a case-control study.
Gastroenterology.
2010;
138
S-16
5
Jung K W, Dunagan K T, Fredericksen M. et al .
Natural history of intestinal metaplasia of the gastroesophageal junction in Olmsted County, MN: a population based cohort study.
Gastrointest Endosc.
2010;
71
AB121
6
Shariff K M, Bird-Lieberman E L, Vowler S L. et al .
Nasal or standard endoscopy (NOSE) for diagnosis of Barrett’s oesophagus – efficacy and patient tolerance.
Gastrointest Endosc.
2010;
71
AB121
7
Kadri S R, Lao-Sirieix P, O’Donovan M. et al .
A prospective, multicentre study to evaluate a novel non-endoscopic screening device for Barrett’s esophagus in the community setting.
Gastroenterology.
2010;
139
e17
8
Lao-Sirieix P, Boussioutas A, Kadri S R. et al .
Non-endoscopic screening biomarkers for Barrett’s oesophagus: from microarray analysis to the clinic.
Gut.
2009;
58
1451-1459
9
Moran E A, Stark D K, Knipschield M A, Gostout C J.
Comparison of chromoendoscopy directed biopsy vs. random biopsy endoscopic surveillance for Barrett’s esophagus – a prospective trial.
Gastrointest Endosc.
2010;
71
AB122
10
Ngamruengphong S, Sharma V K, Das A.
Diagnostic yield of methylene blue chromoendoscopy for detecting specialized intestinal metaplasia and dysplasia in Barrett’s esophagus: a meta-analysis.
Gastrointest Endosc.
2009;
69
1021-1028
11
Pohl H, Rösch T, Vieth M. et al .
Miniprobe confocal laser microscopy for the detection of invisible neoplasia in patients with Barrett’s oesophagus.
Gut.
2008;
57
1648-1653
12
Sharma P, Meining A, Coron E. et al .
Detection of neoplastic tissue in Barrett’s esophagus with in vivo probe-based confocal endomicroscopy (DONT BIOPCE). Final results of a prospective international RCT: image guided versus 4 quadrant random biopsies?.
Gastroenterology.
2010;
138
S-155
13
Anastassiades C P, Li M, Turgeon D K, Piraka C R.
Validation of targeted detection of dysplasia in Barrett’s esophagus with a novel fluorescence-labeled peptide.
Gastroenterology.
2010;
138
S-155-S-156
14
Fleischer D E, Overholt B F, Sharma V K. et al .
Endoscopic ablation of Barrett’s esophagus: a multicenter study with 2.5-year follow-up.
Gastrointest Endosc.
2008;
68
867-876
16
Pouw R E, Bisschops R, Pech O. et al .
Safety outcomes of balloon-based circumferential radiofrequency ablation after focal endoscopic resection of early Barrett’s neoplasia in 118 patients: results of an ongoing European multicenter study.
Gastrointest Endosc.
2010;
71
AB126
17
Pech O, Behrens A, May A. et al .
Long-term results and risk factor analysis for recurrence after curative endoscopic therapy in 349 patients with high-grade intraepithelial neoplasia and mucosal adenocarcinoma in Barrett’s oesophagus.
Gut.
2008;
57
1200-1206
18
Bergman J, Fleischer D E, Yueming Z. et al .
First prospective study on endoscopic radiofrequency ablation of moderate and high-grade intraepithelial squamous neoplasia and early squamous cell cancer of the esophagus.
Gastrointest Endosc.
2010;
71
AB126
19
Fujishiro M, Yahagi N, Kakushima N. et al .
Endoscopic submucosal dissection of esophageal squamous cell neoplasms.
Clin Gastroenterol Hepatol.
2006;
4
688-694
20
Kakushima N, Yahagi N, Fujishiro M. et al .
Efficacy and safety of endoscopic submucosal dissection for tumors of the esophagogastric junction.
Endoscopy.
2006;
38
170-174
21
Deprez P H, Bergman J J, Meisner S. et al .
Current practice with endoscopic submucosal dissection in Europe: position statement from a panel of experts.
Endoscopy.
2010;
Jul 9
DOI: 10.1055/s-0030-1255563
22
Deprez P H, Piessevaux H, Aouattah T. et al .
ESD in Barrett’s esophagus high grade dysplasia and mucosal cancer: prospective comparison with CAP mucosectomy.
Gastrointest Endosc.
2010;
71
AB126
23
Neuhaus H, Mayershofer R, Charton J P. et al .
Endoscopic submucosal resection (ESD) of early Barrett’s neoplasia (EBN) with a Water-Jet Hybridknife (ESDH): first prospective clinical trial.
Gastrointest Endosc.
2010;
71
AB124
24
Neuhaus H, Wirths K, Schenk M. et al .
Randomized controlled study of EMR versus endoscopic submucosal dissection with a water-jet hybrid-knife of esophageal lesions in a porcine model.
Gastrointest Endosc.
2009;
70
112-120
25
Badreddine R J, Prasad G A, Wang K K. et al .
Prevalence and predictors of recurrent neoplasia after ablation of Barrett’s esophagus.
Gastrointest Endosc.
2010;
71
697-703
27
Galmiche J P, Hatlebakk J G, Attwood S E. et al .
Laparoscopic antireflux surgery vs long-term esomeprazole treatment for chronic GERD. Final results after 5 yrs of follow up in the Lotus Study.
Gastroenterology.
2010;
138
S-53
29
Leers J M, Vivaldi C, Schäfer H. et al .
Endoscopic therapy for esophageal perforation or anastomotic leak with a self-expandable metallic stent.
Surg Endosc.
2009;
23
2258-2262
30
Swinnen J, Eisendrath P, Rigaux J. et al .
Self-expandable metallic stents (SEMS) for the treatment of benign upper GI leaks and perforations.
Gastrointest Endosc.
2010;
71
AB132
31
Van Heel N, Haringsma J, Kuipers E J.
Endoscopic extraction of self-expandable metal stents from the esophagus: outcome and complications in 107 procedures.
Gastrointest Endosc.
2010;
71
AB136
33
Yousef F, Bhat S, Mulholland H G. et al .
Low incidence of esophageal adenocarcinoma in Barrett’s esophagus – time to rethink surveillance guidelines?.
Gastroenterology.
2010;
138
S-16
Novel endoscopic and nonendoscopic diagnostic tools for Barrett’s esophagus
34
Arora J, Singh M, Gaddam S. et al .
Accuracy and inter-observer variability of in-vivo probe-based confocal laser endomicroscopy criteria for dysplastic vs non dysplastic Barrett’s esophagus (BE).
Gastroenterology.
2010;
138
S-156
35
Curvers W L, van Vilsteren F G, Baak B C. et al .
A multi-centre randomized cross-over trial comparing endoscopic tri-modal imaging (ETMI) with standard endoscopy (SE) for the detection of dysplasia in Barrett’s esophagus (BE) patients with confirmed LGD performed in a non-university setting.
Gastroenterology.
2010;
138
S-155
36
Terry N G, Zhu Y, Guy C D. et al .
Detection of dysplasia in Barrett’s esophagus with angle-resolved low coherence interferometry.
Gastroenterology.
2010;
138
S-666
Treatment of dysplasia and early cancer in the esophagus
37
Fleischer D E, Overholt B F, Sharma V K. et al .
Endoscopic radiofrequency ablation for Barrett’s esophagus: five-year durability outcomes from a prospective multi-center trial.
Gastrointest Endosc.
2010;
71
AB117-AB118
38
Gupta N, Abrams J A, Early D S. et al .
Multi-modality endoscopic therapy for complete eradication of Barrett’s esophagus.
Gastroenterology.
2010;
139
e18
39
Shaheen N J, Fleischer D E, Eisen G M. et al .
Durability of epithelial reversion after radiofrequency ablation: follow-up of the AIM dysplasia trial.
Gastroenterology.
2010;
138
S-16-S-17
40
Zehetner J, DeMeester S R, Ayazi S. et al .
Long-term follow-up after anti-reflux surgery in patients with Barrett’s esophagus.
Gastroenterology.
2010;
138
S-849
