Aktuelle Dermatologie 2010; 36(11): 425-438
DOI: 10.1055/s-0030-1255846
Fort- und Weiterbildung

© Georg Thieme Verlag KG Stuttgart · New York

Topisches Anti-Aging

Topical Anti-AgingC.  Bayerl1
  • 1 Klinik für Dermatologie und Allergologie HSK, Wilhelm-Fresenius-Klinik Wiesbaden
Further Information

Publication History

Publication Date:
25 October 2010 (online)

Lernziele

Die ästhetische Dermatologie hat die Verbesserung der Hautstruktur und eine Verzögerung von Alterungsprozessen im Fokus. Dieser Fortbildungsbeitrag soll Kenntnisse über die Prävention frühzeitiger UV-Alterung der Haut vermitteln. Ziel ist es aber auch, die topischen Maßnahmen zur Reduktion vorzeitiger Hautalterung in ihrer Indikation, der Wirkung – soweit bekannt – und hinsichtlich der Effizienz einschätzen zu können. Dies ist Voraussetzung für eine vernünftige Beratung im Patientengespräch.

Literatur

  • 1 Bayerl C. Topical treatment of skin aging.  Hautarzt. 2005;  56 330-334; 336 – 339
  • 2 Touitou E, Godin B. Skin nonpenetrating sunscreens for cosmetic and pharmaceutical formulations.  Clin Dermatol. 2008;  26 375-379
  • 3 Ekanayake-Mudiyanselage S, Thiele J. Die Talgdrüse als Transporter für Vitamin E.  Hautarzt. 2006;  57 291-296
  • 4 Berneburg M, Kamenisch Y, Krutmann I. et al . To repair or not to repair – no longer a question: repair of mitochondrial DNA shielding agianst age and cancer.  Exp Dermatol. 2006;  15 1005-1015
  • 5 Fisher G J, Kang S, Varani J. et al . Mechanisms of photoaging and chronological skin aging.  Arch Dermatol. 2002;  138 1462-1470
  • 6 Boukamp P. Ageing mechanisms: the role of telomere loss.  Clin Exp Dermatol. 2001;  26 562-565
  • 7 Podda M, Traber M G, Weber C. et al . UV-irradiation depletes antioxidants and causes oxidative damage in a model of human skin.  Free Rad Biol Med. 1998;  24 55-65
  • 8 Lin J Y, Selim M A, Shea C R. et al . UV photoprotection by combination topical antioxidants vitamin C and vitamin E.  J Am Acad Dermatol. 2003;  48 866-874
  • 9 Nusgens B V, Humbert P, Rougier A. et al . Topically applied Vitamin C enhances the mRNA level of collagen I and III, their processing enzymes and tissue inhibitors of matrix metalloproteinase I in the human dermis.  J Invest Dermatol. 2001;  116 853-859
  • 10 Placzek M, Gaube S, Kerkmann U. et al . Ultraviolet B-Induced DNA damage in human epidermis is modified by the antioxidants ascorbic acid and d-α-tocopherol.  J Invest Dermatol. 2005;  124 304-307
  • 11 Hoppe U, Bergemann J, Diembeck W. et al . Coenzyme Q10, a cutaneous antioxidant and energizer.  Biofactors. 2000;  9 371-378
  • 12 Bissett D L, Miyamoto K, Sun P. et al . Topical niacinamide riduces yellowing, wrinkling, red blotchiness, and hyperpigmented spots in aging facial skin.  Int J Cosmet Eci. 2004;  26 231-238
  • 13 Lenz H, Schmidt M, Welge V. et al . the creatine kinase system in human skin: protective effects of creatine against oxidative and UV damage in vitro and in vivo.  J Invest Dermatol. 2005;  124 443-452
  • 14 Kim S J, Lim M H, Chun I K. et al . Effects of flavonoids of Ginkgo biloba on proliferation of human skin fibroblast.  Skin Pharmacol. 1997;  10 200-205
  • 15 Keum Y S, Park K K, Lee J M. et al . Antioxidant and anti-tumor promoting activities of the methanol extract of heat-processed ginseng.  Cancer Lett. 2000;  150 41-48
  • 16 Keil D, Bayerl C. Phytoöstrogene als Antiaging-Mittel.  Akt Dermatol. 2002;  28 69-73
  • 17 Kang S, Chung J H, Lee J H. et al . Topical N-acetyl cysteine and genistein prevent ultraviolet light induced signaling that leads to photoaging in human skin in vivo.  J Invest Dermatol. 2003;  120 835-841
  • 18 Bayerl C, Keil D. Isoflavonoide in der Behandlung der Hautalterung postmenopausaler Frauen.  Akt Dermatol. 2002;  28 14-18
  • 19 Wei H, Zang X, Wang Y. et al . Inhibition if ultraviolet light-induced oxidative events in the skin an internal organs of hairless mice by isolavone genistein.  Cancer Lett. 2002;  185 21-29
  • 20 Katiyar S K, Perez A, Mukhtar H. Green tea polyphenol treatment to human skin prevents formation of ultraviolet light B-induced pyrimidine dimers in DNA.  Clin Canc Res. 2000;  6 3864-3869
  • 21 Baxter R A. Anti-aging properties of resveratrol: review and report of a potent new antioxidant skin care formulation.  J Cosmet Dermatol. 2008;  7 2-7
  • 22 Zaid M A, Afaq F, Syed D N. et al . Inhibition of UVB-mediated oxidative stress and markers of photoaging in immortalized HaCaT keratinocytes by pomegranate polyphenol extract POMx.  Photochem Photobiol. 2008;  83 882-888
  • 23 Saurat J H, Didierjean L, Masgrau E. et al . Topical retinaldehyde on human skin: biologic effects and tolerance.  J Invest Dermatol. 1994;  103 770-774
  • 24 Griffiths C EM, Kang S, Ellis C N. et al . Two concentrations of topical tretinoin (retinoic acid) cause similar improvement of photoaging but different degrees of irritation.  Arch Dermatol. 1995;  131 1037-1044
  • 25 Kang S, Leydon J J, Lowe N J. et al . Tazarotene cream for the treatment of facial photodamage: a multicenter, investigator-masked, randomized, vehicle-controlled, parallel comparison of 0,01 %, 0,05 %, and 0,1 % tazarotene creams with 0,05 % tretinoin emollient cream applied once daily for 24 weeks.  Arch Dermatol. 2001;  137 1597-1604
  • 26 Zouboulis C C. The human skin as a hormone target and an endocrine gland.  Hormones. 2004;  3 9-26
  • 27 Thornton M J. The biological actions of estrogens on skin.  Exp Dermatol. 2003;  11 487-502
  • 28 Makrantonaki E, Zouboulis C C. Molecular mechanisms of skin aging – State-of-the-art.  Ann NY Acad Sci. 2007;  1119 40-50
  • 29 Varila E, Rantala I, Oikarinen A. et al . The effect of topical estradiol on skin collagen of postmenopausal women.  Br J Obst Gynaecol. 1995;  102 985-989
  • 30 Rittié L, Kang S, Voorhees J J. et al . Induction of collagen by estradiol: difference between sun protected and photodamaged human skin in vivo.  Arch Dermatol. 2008;  144 1129-1140
  • 31 Bangha E, Elsner P, Kistler G S. Suppression of UV-induced erythema by topical treatment with melatonin (N-acetyl-5-methoxytryptamine). A dose response?.  Arch Dermatol Res. 1996;  288 522-526
  • 32 Robinson L, Fitzgerald N, Doughty D G. et al . Topical Palmitoyl Pentapeptide provides improvement in photoaged human facial skin.  Int J Cosmet Sci. 2005;  27 155-160
  • 33 Maquart F X, Pickart L, Laurent M. et al . Stimulation of collagen synthesis in fibroblast cultures by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+.  FEBS Lett. 1988;  238 343-346
  • 34 Pickart L. The human tri-peptide GHK and tissue remodeling.  J Biomater Sci Ed. 2008;  19 969-988
  • 35 Morisette G, Germain L, Marceau F. the antiowrinkel effect of topical concentrated 2-dimethylaminoethanol involves vacuolar cytopathology.  Br J Dermatol. 2007;  156 433-439
  • 36 Uhoda L, Faska N, Robert C. et al . Split face study in the cutaneous tensile effect of 2-dimethylaminoethanol (deanol) gel.  Skin Res Technol. 2002;  8 164-167
  • 37 Smith K, Hamza S, Germain M. et al . Does imiquimod histologically rejuvenate ultraviolet radiation damaged skin?.  Dermatol Surg. 2007;  33 1419-1428
  • 38 Chiu P-C, Chan C-C, Lin H-M. et al . The clinical anti-aging effects of topical kinetin and niacinamide in Asians: a randomized double-blind, placebo-controlled, split-face comparative trial.  J Cosmet Derm. 2007;  6 243-249
  • 39 Rattan S I, Sodogam L. Gerontomodulatory and youth-preserving effects of zeatin on human skin fibroblasts undergoing aging in vitro.  Rejuvenation Res. 2005;  8 46-47
  • 40 McCullogh J L, Garcia R L, Reece B. A clinical study of topical pyratine 6 for improving the appearance of photodamaged skin.  J Drugs Derm. 2008;  7 131-135
  • 41 Ehrlich M, Rao J, Pabby A, Goldman M P. et al . Improvement in the appearance of wrinkels with topical transforming growth factor β-1 and L-ascorbic acid.  Dermatol Surg. 2006;  32 618-625
  • 42 Mehta R C, Smith S R, Grove G L. et al . Reduction in facial photodamage by a topical growth factor product.  J Drugs Dermatol. 2008;  7 864-871
  • 43 Gold M H, Goldman M P, Biron J. Human growth factor and cytokine skin cream for facial rejuvantion as assessed by 3D in vivo optical skin imaging.  J Drugs Dermatol. 2007;  6 197-201
  • 44 Bayerl C, Worret I. Chemisches Peeling. Leitlinien der Arbeitsgemeinschaft für ästhetische Dermatologie und Kosmetologie e. V. (ADK) der DDG.  Aesthetische Dermatologie. 2003;  4 34-41
  • 45 Bayerl C. Chemisches Peeling. In: Worret W-I, Gehring W (Hrsg) Kosmetische Dermatologie. Berlin, Heidelberg; Springer 2004: 189-195
  • 46 Walker T, Wiest L, Boer A. et al . Deep Chemical Peeling with Phenole – Renaissance of a gold standard.  Akt Dermatol. 36;  3 73-82
  • 47 Nelson B R, Fader D J, Gillard M. et al . Pilot histologic and ultrastructural study of the effects of medium depth facial peels on dermal collagen in patients with actinically damaged skin.  J Am Acad Dermatol. 1995;  132 472-478
  • 48 Kim S J, Park J H, Kim D H. et al . Increased in vivo collagen synthesis and in vitro cell proliferative effect of glycolic acid.  Dermatol Surg. 1998;  24 1054-1058
  • 49 Ditre C M, Griffith T D, Murphy G F. et al . Effects of α-hydroxy acids on photoaged skin: a pilot clinical, histologic, and ultrastructural study.  J Am Acad Dermatol. 1996;  34 187-195
  • 50 Hermanns J F, Petit L, Martalo O. et al . Unraveling the patterns of subclinical phaeomelanin-enriched facial hyperpigmentation: effect of depigmenting agents.  Dermatology. 2000;  201 118-122
  • 51 Worret W-I, Gehring W (Hrsg). Kosmetische Dermatologie. Berlin, Heidelberg; Springer 2004
  • 52 Orringer J S, Hammerberg C, Hamilton T. et al . Molecular effects of photodynamic therapy for photoaging.  Arch Dermatol. 2008;  144 1296-1302
  • 53 Zane C, Capezzera R, Sala R. et al . Clinical and echographic analysis of photodynamic therapy using methylaminolevulinate as sensitizer in the treatment of photodamaged facial skin.  Lasers Surg Med. 2007;  39 203-209

Prof. Dr. med. Christiane Bayerl

Chefärztin der Klinik für Dermatologie und Allergologie
HSK, Wilhelm-Fresenius-Klinik

Aukammallee 39
65191 Wiesbaden

Email: christiane.bayerl@hsk-wiesbaden.de