Z Gastroenterol 2010; 48 - A7
DOI: 10.1055/s-0030-1254745

Secunder prevention of prostate cancer progression with bioactive agents from natural sources to have life quality under control

A Blázovics 1, P Nyirády 2, K Szentmihályi 3, G Bekő 4, M Sz((udblac)cs 2, I Romics 2, E Sárdi 5
  • 1Department of Pharmacognosy, Semmelweis University
  • 2Department of Urology and Urooncological Centre, Semmelweis University
  • 3Institute of Materials and Environmental Chemistry CRC HAS
  • 4Central Laboratory (Pest), Semmelweis University
  • 5Department of Genetic and Plant Breeding, Faculty of Horticultural Science, Corvinus University of Budapest

Introduction/Aims: Treating different cancers is a major challenge nowadays. Several molecules on the cell surface, in the cell particles and genes can be targets to inhibit the growth of cancerous cells or to stop metastatic processes. Microtubule stabilizer taxanes are molecules which induce microtubule banding, formation of multi-polar spindles and mitotic arrest. In these processes, the transmethylating ability is reduced significantly. Bounded HCHO concentration of erythrocytes in taxane treated patients was significantly lower than in the case of controls. Protoporphyrin concentration was also very low in patients without metastasis, but wery high otherwise. Significant changes of total scavenger capacity and metal element concentrations in erythrocyte can be observed as well, which are very important indexes in cancerous processes. Epidemiological, experimental and clinical investigations have shown that food supplements are not effective in cancer therapy because of inappropriate usage in spite of people suffering from cancers with low vitamin and trace element levels.

Therefore we have looked for a special supplementation, which improves the erytrocyte function of prostate cancer cases.

Methods: Taxane administered patients (N=18) were treated with Beta vulgaris L. ssp. esculenta var. rubra liophylised powder (Permission number: 1361/004/2003 BFÁÉÉÁ) for one month with a dose of two special spoonfuls of lyophilised powder per day. Routine laboratory immunological and biochemical measurements were carried out.

Results: Special components of table beet could modify the erytrocyte total scavenger capacity and element concentrations as well as improve the transmethylating ability. At the same time VEGF was not changed, althought EGF was higher (p=0.003), and PSA and fPSA were elevated non significantly after supplementary. The lewels of IFNG and MCP1 were decreased in small amounts in the sera.

Conclusion: Table beet supplementation must be observed by oncologists. Support: ETT002–02, ETT12/2006