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Homœopathic Links 2011; 24(2): 97-105
DOI: 10.1055/s-0030-1250712
DOI: 10.1055/s-0030-1250712
MATERIA MEDICA AND CASES
© Sonntag Verlag in MVS Medizinverlage Stuttgart GmbH & Co. KG
Autism – A Three Stage Approach
Further Information
Publication History
Publication Date:
25 May 2011 (online)
Summary
This is an article about the complex issues involved in treating autistic children holistically. It covers a synopsis of the basic biochemistry going askew and suggests simplified dietary and nutritional interventions. Two case examples follow to illustrate completion of the treatment with well-chosen homeopathic remedies to stimulate the body's healing mechanisms finally out of the autistic expression.
Key words
Autistic spectrum disorder - Immune system - Dysbacteriosis - Holistic - Individualization - Nutrition - Hyoscyamus - Theridion
References
- 1 Jepson B. Changing the Course of Autism: a scientific Approach for Parents and Physicians. Boulder: Sentient Publications; 2007
- 2 Hertz-Picciotto I, Delwiche L. The rise in autism and the role of age at diagnosis. Epidemiology. 2009; 20 622-623
- 3 Buxbaum J. Multiple rare variants in the etiology of autistic spectrum disorders. Dialogues Clin Neurosci. 2009; 11 35-43
- 4 Folstein S, Rosen-Sheidley B. Genetics of autism: complex aetiology for a heterogeneous disorder. Nature Review Genetics. 2001; 2 943-955
- 5 Steyaert J, De La Marche W. What's new in autism?. Eur J Pediatr. 2008; 167 1091-1101
- 6 Larsson H J, Eaton W W, Madsen K M et al. Risk factors for autism: perinatal factors, parental psychiatric history and socioeconomic status. Am J Epidemiol. 2005; 101 916-925
- 7 Palkovicova L et al. Maternal amalgam dental fillings as the source of mercury exposure in developing fetus and newborn. J Expo Sci Environ Epidemiol. 2008; 18 326-331
- 8 Geier D et al. A prospective study of prenatal mercury exposure from maternal dental amalgams and autism severity. Acta Neurobiol Exp. 2009; 69 189-197
- 9 Bradstreet J et al. A case control study of mercury burden in children with autistic spectrum disorders. J Am Phys and Surg. 2003; 8 76-79
- 10 Desoto M et al. Blood levels of mercury are related to diagnosis of autism: a reanalysis of an important data set. J Child Neurol. 2007; 22 1308-1311
- 11 Adams J et al. Mercury, lead and zinc in baby teeth of children with autism compared to controls. J Toxicol Environ Health Part A. 2007; 70 1046-1051
- 12 Nataf R et al. Porphyrinuria in childhood autistic disorder: implications for environmental toxicity. Toxicol Appl Pharmacol. 2006; 214 99-108
- 13 Gayle C et al. Autism spectrum disorders in relation to distribution of hazardous air pollutants in the San Francisco Bay Area. Environ Health Perspect. 2006; 114 1438-1444
- 14 Nelson K, Bauman M. Thimerosal and autism?. Pediatrics. 2003; 111 674-679
- 15 DeStefano F et al. Age at first measles-mumps-rubella vaccination in children with autism and school-matched control subjects: a population-based study in metropolitan Atlanta. Pediatrics. 2004; 113 259-266
- 16 Richler J et al. Is there a “regressive phenotype” of autistism spectrum disorder associated with the measles-mumps-rubella vaccine? A CPEA study. J Autism Dev Dis. 2006; 36 299-316
- 17 Fombonne E. The prevalence of autism. JAMA. 2003; 45 731-738
- 18 Levisohn P. The autism-epilepsy connection. Epilepsia. 2007; 48 (Suppl. 9) 33-35
- 19 Kanner L. Autistic disturbances of affective contact. Nerv Child. 1943; 2 217-250
- 20 Dapretto M et al. Understanding emotions in others: mirror dysfunction in children with autism spectrum disorders. Nature Neuroscience. 2006; 9 28-30
- 21 Baron-Cohen S et al. Does the autistic child have a theory of mind?. Cognition. 1985; 21 37-46
- 22 Ferrante P et al. Significant association of HLA A2-DR11 with CD4 naïve decrease in autistic children. Biomed Pharmacother. 2003; 57 372-374
- 23 Warren R et al. Deficiency of suppressor-inducer (CD4+CD45RA+) T cells in autism. Immunol Invest. 1990; 19 245-251
- 24 Yonk L et al. CD4+ helper T cell depression in autism. Immunol Lett. 1990; 25 341-345
- 25 Malloy C et al. Elevated cytokines in children with autistic spectrum disorder. J Neuroimmunol. 2006; 172 198-205
- 26 Jyonouchi H et al. Pro-inflammatory and regulatory cytokine production associated with innate and adaptive immune responses in children with autism spectrum disorders and developmental regression. Journal of Neuroimmunology. 2001; 120 170-179
- 27 Jyonouchi H et al. Dysregulated innate immune responses in young children with autism spectrum disorders: their relationship with gastrointestinal symptoms and dietary intervention. Neuropsychobiology. 2005; 51 77-85
- 28 Torrente F et al. Small intestinal enteropathy with epithelial IgG and complement deposition in children with regressive autism. Mol Psychiatry. 2002; 7 378-382
- 29 Ashwood P et al. Spontaneous mucosal lymphocyte cytokine profiles in children with autism and gastrointestinal symptoms: mucosal immune activation and reduced counter regulatory interleukin-10. J Clin Immunol. 2004; 24 664-673
- 30 Ashwood P et al. Intestinal lymphocyte populations in children with regressive autism: evidence for extensive mucosal immunopathology. J Clin Immunol. 2003; 23 504-516
- 31 Wakefield A et al. Ileal-lymphoid nodular hyperplasia, non specific colitis, and developmental disorder in children. Lancet. 1998; 351 637-641
-
32 Cosford R. Vaccination, early infections; antibiotic use and the connection with gastrointestinal dysbiosis and autism in children. Lecture at Autism-Europe Congress, Glasgow, May 2000
- 33 D'Eufemia P et al. Abnormal intestinal permeability in children with autism. Acta Paediatrica. 1996; 85 1076-1079
- 34 Waring R, Klovrza L. Sulphur metabolism in autism. J Nutr Envir Med. 2000; 10 25-32
- 35 Song Y et al. Real-time PCR quantitation of Clostridia in feces of autistic children. Applied and Environmental Microbiology. 2004; 7 6459-6465
- 36 Campbell-McBride N. Gut and Psychology Syndrome. Cambridge: Medinform Publishing; 2004
- 37 Richardson A. Fatty acid metabolism in neurodevelopmental disorder: a new perspective on association between ADHD, dyslexia, dyspraxia, and the autistic spectrum. Prostaglandins. Leucot E Fatty Acids. 2000; 63 1-9
- 38 Reicheld K et al. Possible role of peptides, exorphins and serotonin uptake stimulating peptides in autism. Conference proceedings from “Living and Learning with Autism” University of Durham; 1997: 221-231
- 39 Vojdani A et al. Immune response to dietary proteins, gliadin and cerebellar peptides in children with autism. Nutr Neurosci. 2004; 7 151-161
- 40 Shattock P, Lowdon G. Proteins, peptides and autism. Part 2: Implications for the education and care of people with autism. Brain Dysfunction. 1991; 4 323-334
- 41 Shattock P et al. Role of neuropeptides in autism and their relationship with classical neurotransmitters. Brain Dysfunction. 1990; 3 328-345
- 42 Whiteley P et al. A gluten-free diet as an intervention for autism and associated spectrum disorders: preliminary findings. Autism. 1999; 3 45
- 43 Knivsberg A M et al. Dietary intervention in autistic syndromes. Brain Dysfunction. 1990; 3 315-317
- 44 Knivsberg A M et al. Autistic syndromes and diet: a follow-up study. Scand J Edu Res. 1995; 39 223-236
- 45 Knivsberg A M et al. A randomised, controlled study of dietary intervention in autistic syndromes. Nutr Neurosci. 2002; 5 251-261
- 46 Waring R, Ngong J. Sulphate metabolism in allergy induced autism: relevance to disease aetiology. Conference proceedings from Biological perspectives in autism University of Durham; 1993: 35-44
- 47 Alberti A et al. A sulphation deficit in autistic children: a pilot study. Biological Psychiatry. 1999; 8 420-424
- 48 Deth R et al. How environmental and genetic factors combine to cause autism: a redox/methylation hypothesis. Neurotoxicology. 2008; 29 190-201
- 49 Muravchick S, Levy R J. Clinical implications of mitochondrial dysfunction. Anesthesiology. 2006; 105 819-837
- 50 Rossignol D, Bradstreet J. Evidence of mitochondrial dysfunction in autism and implications for treatment. Am J Biochem & Technol. 2008; 4 208-217
- 51 Sajdel-Sulkowska E et al. Oxidative stress in autism: elevated cerebellar 3-nitrotyrosine levels. Am J Biochem & Technol. 2008; 4 73-84
- 52 Chauhan A et al. Oxidative stress in autism: increased lipid peroxidation and reduced serum levels of ceruloplasmin and transferring – the antioxidant proteins. Life Sci. 2004; 75 2539-2549
- 53 James S et al. Metabolic markers of increased oxidative stress and impaired methylation capacity in children with autism. Am J Clin Nutr. 2004; 80 1611-1617
- 54 Ischiropoulos H, Beckman J S. Oxidative stress and nitration in neurodegeneration: cause, effect or association?. J Clin Invest. 2003; 111 163-169
- 55 Kern J K, Jones A M. Evidence of toxicity, oxidative stress and neuronal insult in autism. J Toxicol Environ Health B Crit Rev. 2006; 9 485-499
- 56 James S et al. Metabolic endophenotype and related genotypes are associated with oxidative stress in children with autism. Am J Med Genet B Neuropsychiatr Genet. 2006; 141 947-956
- 57 Vargas D et al. Neuronal activation and neuroinflammation in the brain of patients with autism. Ann Neurol. 2005; 57 67-81
- 58 Connolly A et al. Brain-derived neurotrophic factor and autoantibodies to neuronal antigens in sera of children with Autistic Spectrum Disorders, Landau-Kleffner Syndrome and Epilepsy. Biol Psych. 2006; 59 354-363
- 59 Geier D et al. Biomarkers of environmental toxicity and susceptibility in autism. J Neurol Sci. 2009; 280 101-108
- 60 Bull G et al. Indol-3-acryloylglycine (IAG) is a putative diagnostic urinary marker for autism spectrum disorders. Medical Science Monitor. 2003; 9 CR422-CR425
- 61 Nataf R et al. Porphyrinuria in childhood autistic disorder: implications for environmental toxicity. Toxicol Appl Pharmacol. 2006; 214 99-108
- 62 Messahel S et al. Urinary levels of neopterin and biopterin in autism. Neuroscience Letters. 1998; 241 17-20
- 63 Sharpe D, Baker D. Financial issues associated with having a child with autism. J Fam Econ Iss. 2007; 28 246-264
- 64 Ganz M. The lifetime distribution of the incremental societal costs of autism. Arch Pediatr Adolesc Med. 2007; 161 343-349
- 65 Rimland B. The DAN Protocol. San Diego, USA: The Autism Research Institute; 1995
- 66 Shattock P, Whiteley P. The Sunderland Protocol. Autism Research Unit, University of Sunderland, UK; 2000
- 67 Allan C, Lutz W. Life without Bread – How a Low-Carbohydrate Diet can save your Life. Los Angeles: Keats Publishing; 2000
- 68 Baic S, Denby N. Living Gluten-Free for Dummies. Chichester: John Wiley & Sons; 2007
- 69 Gottschall E. Breaking the vicious Cycle: Intestinal Health through Diet. Baltimore, Ontario: Kirkton Press Ltd.; 1994
- 70 van der Hulst R et al. Glutamine and the preservation of gut integrity. Lancet. 1993; 341 1363-1365
- 71 DeFelice K. Enzymes for Autism and other neurological Conditions. 3rd ed. Johnston, IA: Thundersnow Interactive; 2003
- 72 James S et al. Efficacy of methylcobalamin and folinic acid treatment on glutathione redox status in children with autism. Am J Clin Nutr. 2009; 89 1-6
Dr. Anton van Rhijn, MSc, MD, FFHom
Heggeli Helhetsmedisin
Heggelibakken 2
0375 Oslo
Norway
Email: anton.rhijn@gmail.com