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DOI: 10.1055/s-0030-1250663
© Georg Thieme Verlag KG Stuttgart · New York
Current Approaches to Discover Marine Antileishmanial Natural Products
Publication History
received July 14, 2010
revised Nov. 22, 2010
accepted Dec. 2, 2010
Publication Date:
17 January 2011 (online)
![](https://www.thieme-connect.de/media/plantamedica/201106/lookinside/thumbnails/10.1055-s-0030-1250663-1.jpg)
Abstract
Leishmaniasis is a neglected infectious disease caused by kinetoplastid protozoans. An urgent need for novel chemotherapeutics exists. The current approaches to discover new antileishmanial compounds present many drawbacks, including high-cost and time-consuming bioassays. Thus, advances in leishmaniasis treatment are limited, and the development of screening assays is hindered. The combination of multidisciplinary approaches using standardised methods and synchronous projects could be an alternative to develop novel drugs for leishmaniasis treatment. In this review, we discuss the current status of leishmaniasis occurrence and treatment. In addition, we address the advantages and limitations of in vitro leishmaniasis bioassays and discuss the findings of drug discovery research using natural products. Finally, we comprehensively review the marine natural products that are active against Leishmania spp., including their natural sources and bioactivity profile.
Key words
leishmaniasis - drug - therapy - marine natural products - in vitro bioassays - Leishmania
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André G. Tempone
Department of Parasitology
Laboratory of Applied Toxinology on Anti-parasitic Drugs
Instituto Adolfo Lutz
Avenida Dr. Arnaldo, 351, 8° andar
Cerqueira Cesar
CEP 01246-000 – São Paulo/SP
Brazil
Phone: +55 11 30 68 29 91
Fax: +55 11 30 68 28 90
Email: atempone@ial.sp.gov.br