Planta Med 2011; 77(5): 485-488
DOI: 10.1055/s-0030-1250570
Natural Product Chemistry
Letters
© Georg Thieme Verlag KG Stuttgart · New York

Labdane Diterpenoids and Shikimic Acid Derivatives from Araucaria cunninghamii

Jia Chen1 , Jian-Jun Chen1 , Li-Qiong Yang1 , Lei Hua1 , Kun Gao1 , 2
  • 1State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, P. R. China
  • 2School of Biotechnology and Chemical Engineering, Ningbo Institute of Technology, Zhejiang University, Ningbo, P. R. China
Further Information

Publication History

received September 25, 2010 revised October 23, 2010

accepted October 27, 2010

Publication Date:
23 November 2010 (online)

Abstract

Four new (14) and two known compounds (5, 6) were isolated from the aerial parts of Araucaria cunninghamii. By analysis of UV, IR, MS, and NMR, the new compounds were identified as ent-19-(Z)-coumaroyloxylabda-8(17),13(16),14-triene (1), ent-19-(E)-coumaroyloxylabda-8(17),13(16),14-triene (2), shikimic acid n-butyl ester (3), and 5-(Z)-coumaroyloxyquinic acid n-butyl ester (4). Compounds 1 and 6 exhibited inhibitory activity against Escherichia coli, and compound 1 also exhibited moderate activity against human leukemia cells (HL-60) and human hepatoma cells (SMMC-7721) with IC50 values of 8.90 and 11.53 µM, respectively.

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Prof. Kun Gao

Lanzhou University
College of Chemistry and Chemical Engineering

Tianshui South Road 222

Lanzhou 730000

China

Phone: +86 93 18 91 25 92

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Email: npchem@lzu.edu.cn