Three New Terpenoid Indole Alkaloids from Catharanthus roseus

Abstract

Three new terpenoid indole alkaloids, vidolicine (1), normacusine B N-oxide (2), and lochnerine N-oxide (3), together with seven known ones (4–10), were isolated from whole plants of Catharanthus roseus. Their structures were elucidated by spectroscopic methods (NMR, MS, UV, and IR). Cytotoxic activities of these isolates (1–10) were evaluated, but only compound 8 was active against HL-60, SMMC-7721, and A549 cell lines.

Key words

Catharanthus roseus (L.) G. Don - Apocynaceae - terpenoid indole alkaloids - vidolicine - normacusine B N‐oxide - lochnerine N‐oxide - cytotoxic activity

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