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DOI: 10.1055/s-0030-1250526
© Georg Thieme Verlag KG Stuttgart · New York
Antileishmanial Sesquiterpenes from the Brazilian Red Alga Laurencia dendroidea
Publikationsverlauf
received September 22, 2010
revised October 10, 2010
accepted October 13, 2010
Publikationsdatum:
05. November 2010 (online)
![](https://www.thieme-connect.de/media/plantamedica/201107/lookinside/thumbnails/10.1055-s-0030-1250526-1.jpg)
Abstract
Investigation of the bioactive crude extracts from two populations of the red alga Laurencia dendroidea from the southeastern Brazilian coast led to the identification of five sesquiterpenes: (+)-obtusane (1), a triquinane derivative (2), (−)-elatol (3), obtusol (4), and cartilagineol (5). An antileishmanial bioassay against Leishmania amazonensis was conducted for crude lipophilic extracts and for sesquiterpenes 2, 3, and 4. Compounds 3 and 4 displayed in vitro and in vivo leishmanicidal activity and very low cytotoxicity.
Key words
antileishmanial activity - halogenated sesquiterpenes - Laurencia dendroidea J. Agardh - Rhodomelaceae - Leishmania amazonensis Lainson & Shaw
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Angélica Ribeiro Soares
Núcleo de Estudos em Ecologia e Desenvolvimento Sócio-Ambiental de Macaé
Universidade Federal do Rio de Janeiro
Rua Rotary Club s/n° Bairro São José do Barreto
Macaé 27901-000 RJ
Brazil
Telefon: +55 22 27 59 34 31
Fax: +55 22 27 62 93 13
eMail: angelica.r.soares@gmail.com
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