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DOI: 10.1055/s-0030-1250492
© Georg Thieme Verlag KG Stuttgart · New York
New Chalcone and Dimeric Chalcones with 1,4-p-Benzoquinone Residue from Combretum yunnanense
Publikationsverlauf
received June 8, 2010
revised October 1, 2010
accepted October 5, 2010
Publikationsdatum:
04. November 2010 (online)
![](https://www.thieme-connect.de/media/plantamedica/201105/lookinside/thumbnails/10.1055-s-0030-1250492-1.jpg)
Abstract
New chalcone and dimeric chalcones with 1,4-p-benzoquinone residue, combrequinone A (1), combrequinone B (2), and combrequinone C (3), along with three known compounds (4–6), were isolated from the ethanolic extract of the stems and leaves of Combretum yunnanense, and their structures were determined by spectroscopic analysis. Compounds 1–3 were evaluated for in vitro cytotoxicity against five human cancer cell lines: HL-60, SMMC-7721, A-549, MCF-7, and SW480. Compounds 1, 2, and 3 were found to be most potent against HL-60 acute leukemia cells, with IC50 values of 4.63, 4.07, and 1.26 µM, respectively.
Key words
Combretum yunnanense - Combretaceae - combrequinone A - combrequinone B - combrequinone C - cytotoxicity
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Dr. Li-Qin Wang
Department of Chemistry and Chemical Engineering
Yunnan Normal University
121 Street
Kunming 650051
Yunnan
People's Republic of China
Telefon: +86 87 15 51 60 61
Fax: +86 87 15 51 60 61
eMail: lqwang@ynnu.edu.cn
eMail: ygchen48@hotmail.com
Dr. Ye-Gao Chen
Department of Chemistry and Chemical Engineering
Yunnan Normal University
121 Street
Kunming 650051
Yunnan
People's Republic of China
Telefon: +86 87 15 51 60 61
Fax: +86 87 15 51 60 61
eMail: ygchen48@hotmail.com
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