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DOI: 10.1055/s-0030-1250452
© Georg Thieme Verlag KG Stuttgart · New York
Plant Products in the Treatment and Control of Filariasis and Other Helminth Infections and Assay Systems for Antifilarial/Anthelmintic Activity
Publication History
received May 30, 2010
revised Sept. 5, 2010
accepted Sept. 23, 2010
Publication Date:
18 October 2010 (online)
![](https://www.thieme-connect.de/media/plantamedica/201106/lookinside/thumbnails/10.1055-s-0030-1250452-1.jpg)
Abstract
Lymphatic filariasis, onchocerciasis, loaisis, and other helminth infections cause serious health problems especially in resource-limited tropical and subtropical developing countries of the world, and more than 2 billion people are infected with at least one helminth species. From times immemorial, man looked up to the plant kingdom in search of anthelmintics, antifilarials, and remedies for parasite-induced health problems. Although more than 50 % of drugs in modern medicine are derived from plants or leads from plants, a success story of plant-based anthelminthics or antifilarials is yet to be told. In the last 5 decades, more than 100 plant products were reported to be beneficial in the treatment or control of these parasitic infections but they could not be developed into viable drugs for a variety of reasons. This review focuses on the plant products reported to be useful in the control and treatment of human helminth infections with the main emphasis on filariasis and the in vitro and in vivo systems available for assaying anthelmintic activity.
Key words
plant products - filariasis - helminthiasis - in vitro assays - in vivo assays
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Dr. Puvvada Kalpana Murthy
Division of Parasitology
Central Drug Research Institute, CSIR, MG Marg
Lucknow 226001
India
Phone: +91 52 22 61 24 12 18; Extn: 44 27
Fax: +91 52 22 62 34 05; 26 2 39 38; 26 2 95 04
Email: drpkmurthy@yahoo.com