Aktuelle Therapie der Patientin mit einem Mammakarzinom

Zusammenfassung

Die Behandlungsoptionen und auch die Charakteristika zur Therapieentscheidung der Patientin mit einem primären und fortgeschrittenen Mammakarzinom werden immer vielfältiger. Neue zielgerichtete Therapien in Kombination mit etablierten Chemotherapien erweitern das Spektrum, doch potenziell vielversprechende Kombinationen bringen nicht immer ein besseres Ergebnis. Neueste Daten aus der Pharmakogenomik weisen auf Prognose- und Prädiktivfaktoren hin, die nicht nur die Eigenschaften des Tumors, sondern auch die vererbbaren genetischen Eigenschaften der Patientin berušcksichtigen. Die aktuelle Therapieentscheidung ist somit mittlerweile eine Kombination aus klassischerweise klinischen und modernen molekularen Biomarkern. Immer häufiger werden auch gesundheitsökonomische Aspekte berušcksichtigt, sodass auch gesundheitspolitische Überlegungen eine Rolle spielen können. Auf der Jahrestagung der American Society of Clinical Oncology (ASCO) 2010 in Chicago wurden zu allen Aspekten des Therapiealgorithmus beim Mammakarzinom aktuelle Daten vorgestellt und zum Teil kontrovers diskutiert.

Abstract

The treatment options for primary and metastatic breast cancer patients as well as the characteristics considered for therapy decision continue to become more diverse. New target therapies in combination with established chemotherapy regimens extend the range, however, potentially promising combinations do not always result in a benefit for the patient. Latest pharmacogenomics results hint towards prognosis and predictive factors, which do not only focus on the individual properties of the tumor, they also consider the hereditary genetics of the patient. As a result, state of the art therapy decision includes classical clinical as well as modern molecular biomarkers, however, pharmacoeconomic aspects continue to increase in importance in physicians' treatment algorithms. The Annual Meeting of the American Society of Clinical Oncology (ASCO) 2010 in Chicago revealed latest data for all aspects of the breast cancer therapy algorithm and allowed for partially controversial discussions.

Schlüsselwörter

BRCA1 - TOP2A - Aromatasehemmer - zirkulierende Tumorzellen (ZTZ) - QALY

Key words

BRCA1 - TOP2A - aromatase inhibitor - circulating tumor cells (CTC) - QALY

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