Planta Med 2011; 77(6): 631-640
DOI: 10.1055/s-0030-1250405
Tropical Diseases
Reviews
© Georg Thieme Verlag KG Stuttgart · New York

Natural Products Published in 2009 from Plants Traditionally Used to Treat Malaria

Joanne Bero, Joëlle Quetin-Leclercq
  • 1Pharmacognosy Research Group, Louvain Drug Research Institute, Université Catholique de Louvain, Brussels, Belgium
Weitere Informationen

Publikationsverlauf

received June 15, 2010 revised July 29, 2010

accepted Sept. 9, 2010

Publikationsdatum:
19. Oktober 2010 (online)

Abstract

Malaria is a major parasitic disease and is responsible for almost one million deaths each year in Africa. There is an urgent need to discover new active compounds. Nature and particularly plants are a potential source of new antimalarial drugs since they contain a quantity of metabolites with a great variety of structures and pharmacological activities. This review covers the compounds with antiplasmodial activity isolated from plants which have been published during 2009 organized according to their phytochemical classes. Details are given for substances with IC50 values ≤ 11 µM. Sixty-seven references are identified.

References

  • 1 Bilia A R. Non-nitrogenous plant-derived constituents with antiplasmodial activity.  Nat Prod Commun. 2006;  1 1181-1204
  • 2 Caniato R, Puricelli L. Review: natural antimalarial agents (1995–2001).  Crit Rev Plant Sci. 2003;  22 79-105
  • 3 Fournet A, Munoz V. Natural products as trypanocidal, antileishmanial and antimalarial drugs.  Curr Top Med Chem. 2002;  2 1215-1238
  • 4 Phillipson J D. Natural-products as drugs.  Trans R Soc Trop Med Hyg. 1994;  88 17-19
  • 5 Saxena S, Pant N, Jain D C, Bhakuni R S. Antimalarial agents from plant sources.  Curr Sci. 2003;  85 1314-1329
  • 6 Schwikkard S, van Heerden F R. Antimalarial activity of plant metabolites.  Nat Prod Rep. 2002;  19 675-692
  • 7 Wright C W. Plant derived antimalarial agents: new leads and challenges.  Phytochem Rev. 2005;  4 55-61
  • 8 Mambu L, Grellier P. Antimalarial compounds from traditionally used medicinal plants. Colegate SM, Molyneux RJ Bioactive natural products. Detection, isolation and structural determination, 2nd edition. Boca Raton, USA; CRC Press 2008: 491-529
  • 9 Kaur K, Jain M, Kaur T, Jain R. Antimalarials from nature.  Bioorg Med Chem. 2009;  17 3229-3256
  • 10 Bero J, Frederich M, Quetin-Leclercq J. Antimalarial compounds isolated from plants used in traditional medicine.  J Pharm Pharmacol. 2009;  61 1401-1433
  • 11 dos Santos D A P, Braga P A D, da Silva M F D F, Fernandes J B, Vieira P C, Magalhaes A F, Magalhaes E G, Marsaioli A J, Moraes V R D, Rattray L, Croft S L. Anti-African trypanocidal and antimalarial activity of natural flavonoids, dibenzoylmethanes and synthetic analogues.  J Pharm Pharmacol. 2009;  61 257-266
  • 12 Muiva L M, Yenesew A, Derese S, Heydenreich M, Peter M G, Akala H M, Eyase F, Waters N C, Mutai C, Keriko J M, Walsh D. Antiplasmodial β-hydroxydihydrochalcone from seedpods of Tephrosia elata.  Phytochem Lett. 2009;  2 99-102
  • 13 Wahyuni T S, Ekasari W, Widyawaruyanti A, Hirasawa Y, Morita H, Zaini N C. Artopeden A, a new antiplasmodial isoprenylated flavone from Artocarpus champeden.  Heterocycles. 2009;  79 1121-1126
  • 14 da Silva A A, Resende D O, Fukui M J, Santos F F, Pauletti P M, Cunha W R, Silva M L A, Gregorio L E, Bastos J K, Nanayakkara N P D. In vitro antileishmanial, antiplasmodial and cytotoxic activities of phenolics and triterpenoids from Baccharis dracunculifolia D. C. (Asteraceae).  Fitoterapia. 2009;  80 478-482
  • 15 Zelefack F, Guilet D, Fabre N, Bayet C, Chevalley S, Ngouela S, Lenta B N, Valentin A, Tsamo E, Dijoux-Franca M G. Cytotoxic and antiplasmodial xanthones from Pentadesma butyracea.  J Nat Prod. 2009;  72 954-957
  • 16 Laphookhieo S, Maneerat W, Koysomboon S. Antimalarial and cytotoxic phenolic compounds from Cratoxylum maingayi and Cratoxylum cochinchinense.  Molecules. 2009;  14 1389-1395
  • 17 Elfita E, Muharni M, Latief M, Darwati D, Widiyantoro A, Supriyatna S, Bahti H H, Dachriyanus D, Cos P, Maes L, Foubert K, Apers S, Pieters L. Antiplasmodial and other constituents from four Indonesian Garcinia spp.  Phytochemistry. 2009;  70 907-912
  • 18 Chung I M, Ghimire B K, Kang E Y, Moon H I. Antiplasmodial and cytotoxic activity of khellactone derivatives from Angelica purpuraefolia Chung.  Phytother Res. 2010;  24 469-471
  • 19 Flores N, Jimenez I A, Gimenez A, Ruiz G, Gutierrez D, Bourdy G, Bazzocchi I L. Antiparasitic activity of prenylated benzoic acid derivatives from Piper species.  Phytochemistry. 2009;  70 621-627
  • 20 Chung I M, Seo S H, Kang E Y, Park W H, Moon H I. Anti-malarial activity of 6-(8'Z-pentadecenyl)-salicylic acid from Viola websteri in mice.  Malar J. 2009;  8 151
  • 21 Lee S J, Park W H, Moon H I. Bioassay-guided isolation of antiplasmodial anacardic acids derivatives from the whole plants of Viola websteri Hemsl.  Parasitol Res. 2009;  104 463-466
  • 22 Roumy V, Fabre N, Portet B, Bourdy G, Acebey L, Vigor C, Valentin A, Moulis C. Four anti-protozoal and anti-bacterial compounds from Tapirira guianensis.  Phytochemistry. 2009;  70 305-311
  • 23 Oshimi S, Deguchi J, Hirasawa Y, Ekasari W, Widyawaruyanti A, Wahyuni T S, Zaini N C, Shirota O, Morita H. Cassiarins C–E, antiplasmodial alkaloids from the flowers of Cassia siamea.  J Nat Prod. 2009;  72 1899-1901
  • 24 Marti G, Eparvier V, Moretti C, Susplugas S, Prado S, Grellier P, Retailleau P, Gueritte F, Litaudon M. Antiplasmodial benzophenones from the trunk latex of Moronobea coccinea (Clusiaceae).  Phytochemistry. 2009;  70 75-85
  • 25 Seephonkai P, Sangdee A, Bunchalee P, Pyne S G. Cytotoxic and antiplasmodial compounds from the roots of Strophioblachia fimbricalyx.  J Nat Prod. 2009;  72 1892-1894
  • 26 Hou Y, Cao S, Brodie P J, Callmander M W, Ratovoson F, Rakotobe E A, Rasamison V E, Ratsimbason M, Alumasa J N, Roepe P D, Kingston D G I. Antiproliferative and antimalarial anthraquinones of Scutia myrtina from the Madagascar forest.  Bioorg Med Chem. 2009;  17 2871-2876
  • 27 Noungoue D T, Chaabi M, Ngouela S, Antheaume C, Boyom F F, Gut J, Rosenthal P J, Lobstein A, Tsamo E. Antimalarial compounds from the stem bark of Vismia laurentii.  Z Naturforsch (C). 2009;  64 210-214
  • 28 Dettrakul S, Surerum S, Rajviroongit S, Kittakoop P. Biomimetic transformation and biological activities of globiferin, a terpenoid benzoquinone from Cordia globifera.  J Nat Prod. 2009;  72 861-865
  • 29 Efange S M N, Brun R, Wittlin S, Connolly J D, Hoye T R, McAkam T, Makolo F L, Mbah J A, Nelson D P, Nyongbela K D, Wirmum C K. Okundoperoxide, a bicyclic cyclofarnesylsesquiterpene endoperoxide from Scleria striatinux with antiplasmodial activity.  J Nat Prod. 2009;  72 280-283
  • 30 Henchiri H, Bodo B, Deville A, Dubost L, Zourgui L, Raies A, Grellier P, Mambu L. Sesquiterpenoids from Teucrium ramosissimum.  Phytochemistry. 2009;  70 1435-1441
  • 31 Lategan C A, Campbell W E, Seaman T, Smith P J. The bioactivity of novel furanoterpenoids isolated from Siphonochilus aethiopicus.  J Ethnopharmacol. 2009;  121 92-97
  • 32 Pedersen M M, Chukwujekwu J C, Lategan C A, Van Staden J, Smith P J, Staerk D. Antimalarial sesquiterpene lactones from Distephanus angulifolius.  Phytochemistry. 2009;  70 601-607
  • 33 Nour A M M, Khalid S A, Kaiser M, Brun R, Abdallah W E, Schmidt T J. The antiprotozoal activity of sixteen Asteraceae species native to Sudan and bioactivity-guided isolation of xanthanolides from Xanthium brasilicum.  Planta Med. 2009;  75 1363-1368
  • 34 Chung I M, Moon H I. Antiplasmodial activities of sesquiterpene lactone from Carpesium cernum.  J Enzym Inhib Med Chem. 2009;  24 131-135
  • 35 Kim J J, Chung I M, Jung J C, Kim M Y, Moon H I. In vivo antiplasmodial activity of 11(13)-dehydroivaxillin from Carpesium ceruum.  J Enzym Inhib Med Chem. 2009;  24 247-250
  • 36 Lekphrom R, Kanokmedhakul S, Kanokmedhakul K. Bioactive diterpenes from the aerial parts of Anisochilus harmandii.  Planta Med. 2010;  76 726-728
  • 37 Sutthivaiyakit S, Mongkolvisut W, Prabpai S, Kongsaeree P. Diterpenes, sesquiterpenes, and a sesquiterpene-coumarin conjugate from Jatropha integerrima.  J Nat Prod. 2009;  72 2024-2027
  • 38 Cachet N, Hoakwie F, Bertani S, Bourdy G, Deharo E, Stien D, Houel E, Gornitzka H, Fillaux J, Chevalley S, Valentin A, Jullian V. Antimalarial activity of simalikalactone E, a new quassinoid from Quassia amara L. (Simaroubaceae).  Antimicrob Agents Chemother. 2009;  53 4393-4398
  • 39 Oshimi S, Takasaki A, Hirasawa Y, Hosoya T, Awang K, Hadi A H A, Ekasari W, Widyawaruyanti A, Morita H. Delaumonones A and B, new antiplasmodial quassinoids from Laumoniera bruceadelpha.  Chem Pharm Bull. 2009;  57 867-869
  • 40 Houel E, Bertani S, Bourdy G, Deharo E, Jullian V, Valentin A, Chevalley S, Stien D. Quassinoid constituents of Quassia amara L. leaf herbal tea. Impact on its antimalarial activity and cytotoxicity.  J Ethnopharmacol. 2009;  126 114-118
  • 41 Silva E C C, Cavalcanti B C, Amorim R C N, Lucena J F, Quadros D S, Tadei W P, Montenegro R C, Costa-Lotufo L V, Pessoa C, Moraes M O, Nunomura R C S, Nunomura S M, Melo M R S, Andrade-Neto V F, Silva L F R, Vieira P P R, Pohlit A M. Biological activity of neosergeolide and isobrucein B (and two semi-synthetic derivatives) isolated from the Amazonian medicinal plant Picrolemma sprucei (Simaroubaceae).  Mem Inst Oswaldo Cruz. 2009;  104 48-55
  • 42 Mohamad K, Hirasawa Y, Litaudon M, Awang K, Hadi A H A, Takeya K, Ekasari W, Widyawaruyanti A, Zaini N C, Morita H. Ceramicines B–D, new antiplasmodial limonoids from Chisocheton ceramicus.  Bioorg Med Chem. 2009;  17 727-730
  • 43 Samoylenko V, Jacob M R, Khan S I, Zhao J P, Tekwani B L, Midiwo J O, Walker L A, Muhammad I. Antimicrobial, antiparasitic and cytotoxic spermine alkaloids from Albizia schimperiana.  Nat Prod Commun. 2009;  4 791-796
  • 44 Samoylenko V, Ashfaq M K, Jacob M R, Tekwani B L, Khan S I, Manly S P, Joshi V C, Walker L A, Muhammad I. Indolizidine, antiinfective and antiparasitic compounds from Prosopis glandulosa var. glandulosa.  J Nat Prod. 2009;  72 92-98
  • 45 Wangchuk P, Bremner J B, Samten, Rattanajak R, Kamchonwongpaisan S. Antiplasmodial agents from the Bhutanese medicinal plant Corydalis calliantha.  Phytother Res. 2010;  24 481-485
  • 46 Buchanan M S, Davis R A, Duffy S, Avery V M, Quinn R J. Antimalarial benzylisoquinoline alkaloid from the rainforest tree Doryphora sassafras.  J Nat Prod. 2009;  72 1541-1543
  • 47 Fernandez L S, Buchanan M S, Carroll A R, Feng Y J, Quinn R J, Avery V M. Flinderoles A-C: antimalarial bis-indole alkaloids from Flindersia species.  Org Lett. 2009;  11 329-332
  • 48 Hirasawa Y, Arai H, Zaima K, Oktarina R, Rahman A, Ekasari W, Widyawaruyanti A, Indrayanto G, Zaini N C, Morita H. Alstiphyllanines A-D, indole alkaloids from Alstonia macrophylla.  J Nat Prod. 2009;  72 304-307
  • 49 Mueller D, Davis R A, Duffy S, Avery V M, Camp D, Quinn R J. Antimalarial activity of azafluorenone alkaloids from the Australian tree Mitrephora diversifolia.  J Nat Prod. 2009;  72 1538-1540
  • 50 Lekphrom R, Kanokmedhakul S, Kanokmedhakul K. Bioactive styryllactones and alkaloid from flowers of Goniothalamus laoticus.  J Ethnopharmacol. 2009;  125 47-50
  • 51 Tobinaga S, Sharma M K, Aalbersberg W G L, Watanabe K, Iguchi K, Narui K, Sasatsu M, Waki S. Isolation and identification of a potent antimalarial and antibacterial polyacetylene from Bidens pilosa.  Planta Med. 2009;  75 624-628
  • 52 Soh P N, Witkowski B, Olagnier D, Nicolau M L, Garcia-Alvarez M C, Berry A, Benoit-Vical F. In vitro and in vivo properties of ellagic acid in malaria treatment.  Antimicrob Agents Chemother. 2009;  53 1100-1106
  • 53 Verotta L, Dell'Agli M, Giolito A, Guerrini M, Cabalion P, Bosisio E. In vitro antiplasmodial activity of extracts of Tristaniopsis species and identification of the active constituents: ellagic acid and 3,4,5-trimethoxyphenyl-(6'-O-galloyl)-O-beta-D-glucopyranoside.  J Nat Prod. 2001;  64 603-607
  • 54 Phillipson J D, Wright C W. Antiprotozoal agents from plant sources.  Planta Med. 1991;  57 S53-S59
  • 55 Kalauni S K, Awale S, Tezuka Y, Banskota A H, Linn T Z, Asih P B S, Syafruddin D, Kadota S. Antimalarial activity of cassane- and norcassane-type diterpenes from Caesalpinia crista and their structure-activity relationship.  Biol Pharm Bull. 2006;  29 1050-1052
  • 56 Linn T Z, Awale S, Tezuka Y, Banskota A H, Kalauni S K, Attamimi F, Ueda J, Asih P B S, Syafruddin D, Tanaka K, Kadota S. Cassane- and norcassane-type diterpenes from Caesalpinia crista of Indonesia and their antimalarial activity against the growth of Plasmodium falciparum.  J Nat Prod. 2005;  68 706-710

Joanne Bero

Pharmacognosy Research Group
Louvain Drug Research Institute
Université Catholique de Louvain

Avenue E. Mounier 72

1200 Brussels

Belgium

Telefon: +32 27 64 72 92

Fax: +32 27 64 72 93

eMail: Joanne.bero@uclouvain.be