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Psychiatrie und Psychotherapie up2date 2010; 4(05): 297-304
DOI: 10.1055/s-0030-1248515
Schizophrenien und andere psychotische Störungen

Neues zur Genetik der Schizophrenie

Rainald Mössner
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  • In den letzten beiden Jahren wurden große Fortschritte in der Aufklärung der Pathogenese der Schizophrenie erzielt.

  • Genetische Ursachen sind vermutlich für etwa 80 % aller Schizophrenieerkrankungen verantwortlich.

  • Aus der klinischen Beobachtung des häufigen Nikotinabusus bei Schizophreniepatienten ergaben sich neue Erkenntnisse zu Endophänotypen der Schizophrenie.

  • Es wurden eine Reihe neuer Schizophrenierisikogene gefunden. Darüber hinaus sind große Deletionen der DNA an den Chromosomenabschnitten 1q21.1 und 15q13.3 neue pathogenetische Faktoren in der Verursachung der Schizophrenie.

  • Auch sind Fortschritte in der Pharmakogenetik der Schizophrenie erzielt worden.

  • Es ist zu erwarten, dass die kommenden Jahre weitere Erkenntnisse zur Rolle genetischer Befunde in der Diagnostik und Therapie schizophrener Erkrankungen bringen werden.



Publication History

Publication Date:
04 August 2010 (online)

© Georg Thieme Verlag KG Stuttgart · New York

 

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