Zusammenfassung
Mangostane (auch Mangostan, Mangostin; Carcinia mangostana L, Clusiaceae) hat eine lange Geschichte als Heilpflanze, v.a. in Südostasien. Dieser
Artikel gibt einen Überblick über die Pharmakologie der Pflanze. Traditionell ist
Mangostane für ihre entzündungshemmenden Eigenschaften bekannt und wird zur Behandlung
von Hautinfektionen und Wunden verwendet. Andere Anwendungsbereiche umfassen die Therapie
unterschiedlicher Störungen wie Dysenterie, Erkrankungen der Harnwege, Zystitis und
Gonorrhö. Dieser Review-Artikel beleuchtet die Entwicklung der pflanzlichen Droge
zu einem weitverbreiteten Nutraceutical. Produkte aus G. mangostana werden heute weltweit vermarktet. Das hat zu einer vermehrten Erforschung ihrer phytochemischen
Bestandteile und deren biologischer Wirkungen geführt. Ausführlich vorgestellt werden
die biologischen Aktivitäten einzelner Xan-thone sowie Extrakte von G. mangostana. Außerdem wird das Potenzial der Pflanze im Hinblick auf die Entwicklung neuer Wirkstoffe
(oder Leitsubstanzen) beleuchtet. Produkte aus den Früchten werden inzwischen verbreitet
als flüssige pflanzliche Nahrungsergänzungsmittel verkauft, doch Nachweise über die
gesundheitlichen Wirkungen dieser Produkte stehen noch aus. Es fehlen klinische Daten
und noch ist unklar, ob die Erkenntnisse über die pharmakologischen Wirkungen auch
von klinischer Relevanz sind.
Summary
Garcinia mangostana L: a phytochemical and pharmacological review
Garcinia mangostana L. (mangosteen, Clusiaceae) has a long history of use as a medi-cal plant, mostly
in Southeast Asia. Here we review the phytochemistry and pharma-cology of mangosteen.
Traditionally mangosteen is famous for its antiinflammatory properties and is used
in the treatment of skin infections and wounds. Other appli-cations include the therapy
of various conditions such as dysentery, different urinary disorders, cystitis and
gonorrhoea. This review highlights the development of this botanical drug into a widely
used nutraceutical. Products derived from G. mangostana are now increasingly employed all over the world. This has given rise to a concomitant
increase in research on the phytochemical constituents and biological activity of
mangosteen. Central to the biological activity of the species are xanthones. A comprehensive
assessment of the biological activities of individual xanthones as well as extracts
of G. mangostana is included. In addition, its potential in terms of developing novel drug leads is
assessed. Products containing its fruits are now sold widely as ‘liquid botanical
Supplements’, but evidence for the health benefits of these products is still lacking.
As shown here, a serious weakness in our knowledge is the lack of clinical data and
it is not yet clear to what extent the findings about pharmacological activities are
of potential clinical relevance.
Schlüsselwörter
Carcinia mangostana L. - Clusiaceae (Guttiferae) - Mangostane - Xanthone - entzündungshemmend - Nutraceutical
- Nahrungsergänzungsmittel - traditionelle Medizin - Ethnopharmakologie
Key words
Garcinia mangostana L. - Clusiaceae (Guttiferae) - mangosteen - xanthones - anti-inflammatory - nutraceuticals
- traditional medicine - ethnopharmacology
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Prof. Dr. Michael Heinrich
Center for Pharmacognosy and Phytotherapy, The School of Pharmacy (University of London)
29-39 Brunswick Sq.
London WC1 N 1AX, UK
eMail: michael.heinrich@pharmacy.ac.uk
Online
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