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DOI: 10.1055/s-0030-1247565
© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York
Diagnosis of Diabetic Neuropathy Using Simple Somatic and a New Autonomic (Neuropad®) Tests in the Clinical Practice
The modified Neuropathy Disability Score and the new test for sudomotor dysfunction Neuropad stratify patients according to their general risk profile and can be used for complex evaluation of diabetic somatic and autonomic neuropathyPublication History
received 22.06.2009
first decision 06.11.2009
accepted 15.01.2010
Publication Date:
03 March 2010 (online)
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Abstract
Aim: The global spread of diabetes (DM) and the importance of early therapeutic intervention determine the need of simple, inexpensive and sensitive methods for diagnosis of diabetic complications in the general practice. The aim of this study was to assess a new instrument – the plaster Neuropad in diagnosing the sudomotor diabetic dysfunction and to investigate the correlates of Neuropad data with diabetic complications.
Patients and methods: In this cross-sectional study participated 264 inpatients (M/F=126/138) with DM type 1/2 (61/203), mean age 55.4±12.0 and DM duration of 9.3±7.1 years. According to hospital records were registered: anthropometric data; fasting plasma glucose and HbA1c; presence of micro-(retino-, nephro-, neuropathy), and macrovascular (arterial hypertension, coronary artery disease and/or brain vascular disease) complications, and neuropathic symptoms were evaluated. For investigation of somatic DN a modified Neuropathy Disability Score (NDS) and for sudomotor autonomic DN – Neuropad were used.
Results: Neuropad showed the highest between-feet correlation of 0.91 compared to all other individual tests and the NDS. Neuropad was able to separate patients in groups with different general risk profile, including age, duration of DM, presence of coronary and/or brain vascular disease, nephropathy, and retinopathy. Moreover, Neuropad differentiated patient groups by their stage of DN, evaluated by symptoms, diagnosis, the individual somatic tests and with the highest significance – by NDS. Most sensitive for detecting DN was NDS ≥ 3, followed by Achilles reflexes, vibration perception (128 Hz tuning fork) and Neuropad. A borderline or abnormal result of Neuropad showed sensitivity=76.3/79.3, specificity=56.1/42.9, positive=86.3/62.8 and negative=39.5/63.0 predictive values, and diagnostic accuracy 72.2/62.9%, compared to the indices for presence of somatic DN (NDS ≥ 3)/foot at risk (NDS ≥ 6) respectively.
Conclusions: Screening for DN must cover somatic and autonomic disturbances. Neuropad is a new sensitive and appropriate for everyday clinical use test for detecting sudomotor DN and identification of patients at higher risk for chronic diabetes complications.
Key words
diabetic neuropathy - sudomotor dysfunction - NDS - neuropad
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Correspondence
Z. A. KamenovMD, PhD,
Clinic of Endocrinology
Medical University – Sofia
1, G.Sofiiski Str.
1431 Sofia
Bulgaria
Phone: +35/988/7726683
Fax: +35/928/229550
Email: zkamenov@hotmail.com