Thorac Cardiovasc Surg 2010; 58 - P12
DOI: 10.1055/s-0029-1246782

Genetic risk stratification in patients undergoing coronary artery bypass graft (CABG) surgery: relative allele frequencies of leading SNPs associated with CAD/MI

S Eifert 1, 2, C Willenborg 3, C Nelson 4, C Hengstenberg 5, B Reichart 1, J Thompson 4, I König 3, N Samani 4, H Schunkert 2, J Erdmann 2
  • 1Ludwig-Maximilians-Universität, Herzchirurgische Klinik und Poliklinik, München, Germany
  • 2Universität zu Lübeck, Medizinische Klinik II, Lübeck, Germany
  • 3Universität zu Lübeck, Institut für Medizinische Biometrie und Statistik, Lübeck, Germany
  • 4University of Leicester, Department of Cardiovascular Sciences, Leicester, United Kingdom
  • 5Universität Regensburg, Klinik und Poliklinik für Innere Medizin II, Regensburg, Germany

Objectives: Chromosomal loci strongly associating with Coronary Artery Disease (CAD)/Myocardial Infarction (MI) (p<0.00001) have been identified in the Welcome Trust Case Control (WTCCC) and Cardiogenics Consortia: 1p13.3 (rs599839), 2q34 (rs6725887), 3q22.3 (rs9818870), 6p24 (rs12526453), 9p21.3 (rs1333049), 10q11.21 (rs501120), and 12q24 (rs3184504), 12q24.31 (rs2259816), 19p13.3 (rs2228671), 21q22 (rs9982601). They may affect disease severity. Our hypothesis was, that relative allele frequencies of single nucleotide polymorphisms (SNPs) associated with CAD/MI may affect disease severity and in CABG patients, may show a strong genetic association.

Methods: Ten SNPs were investigated by in silico replication in genome wide data of CABG patients (total: 499; 384 men, 115 women) and compared to CAD/MI patients (total: 563; 368 men and 195 women) and healthy controls (total: 2884; 2174 men, 710 women).

Results: All patients showed a median of 11 (range: 4 to 16) risk alleles associated with CAD/MI. In contrast to our hypothesis, allele frequencies were almost alike among CAD/MI and CABG groups and not increased in CABG patients. Highest relative frequency showed MI patients: 26.1% of MI patients showing 11 risk alleles. Among healthy controls, the relative allele frequency measured 21.4% counting for 10 risk alleles. CABG patients demonstrated a relative frequency of 22.2% carrying 10 alleles.

Conclusions: We identified all CAD/MI risk alleles that, individually and in aggregate, substantially affect CABG patients, but there has not been a higher relative allele frequency. The score did not improve risk discrimination among both affected groups (CAD/MI and CABG).