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Klin Monbl Augenheilkd 2010; 227(5): 388-392
DOI: 10.1055/s-0029-1245289
Übersicht

© Georg Thieme Verlag KG Stuttgart · New York

Herpes-simplex-Keratitis. Ein kurzer Überblick zur aktuellen Therapie

Herpes Simplex Keratitis. A Short Overview of the Current TherapyW. Behrens-Baumann1
  • 1Universitäts-Augenklinik, Otto-von-Guericke-Universität Magdeburg
Further Information

Publication History

Eingegangen: 4.2.2010

Angenommen: 14.2.2010

Publication Date:
20 May 2010 (online)

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Zusammenfassung

In dieser Übersicht werden aktuelle Therapieempfehlungen zur Herpes-simplex-Keratitis gegeben. Dabei sind nach einer Literaturrecherche Daten von 2000 bis einschließlich 2009 zusätzlich zu früheren zusammengefasst. Im Wesentlichen werden die medikamentöse Behandlung der oberflächlichen, epithelialen Keratitis, der tiefen, stromalen Keratitis, der Rezidivprophylaxe und der metaherpetischen Keratitis behandelt. Schließlich wird ein Therapieschema präsentiert.

Abstract

In this review the current recommendations for the treatment of Herpes simplex keratitis are given – based on the literature, especially from 2000 till 2009. The medical treatment of epithelial, deep stromal keratitis, the prevention of recurrences and metaherpetic keratitis are discussed. Finally, a therapy scheme is presented.

Schlüsselwörter

Kornea - Infektiologie - Herpes simplex

Key words

cornea - infectiology - herpes simplex

Literatur

  • 1 Wander A H, Centifanto Y M, Kaufman H E. Strain specificity of clinical isolates of herpes simplex virus.  Arch Ophthalmol. 1980;  98 1458-1461
    Google Scholar
  • 2 Kaufman H E, Centifanto-Fitzgerald Y M, Varnell E D. Herpes simplex keratitis.  Ophthalmology. 1983;  90 700-706
    Google Scholar
  • 3 Kaufman H E. Update on antiviral agents.  Ophthalmology. 1985;  92 533-536
    Google Scholar
  • 4 Kaufman H E. A new understanding of ocular herpetic disease.  Am J Ophthalmol. 1982;  33 119-121
    Google Scholar
  • 5 Remeijer L, Maertzdorf J, Doornenbal P et al. Herpes simplex virus 1 transmission through corneal transplantation.  Lancet. 2001;  357 442
    Google Scholar
  • 6 Remeijer L, Maertzdorf J, Buitenwerf J et al. Corneal herpes simplex virus type1 superinfection in patients mit recrudescent herpetic keratitis.  Invest Ophthalmol Vis Sci. 2002;  43  358-363
    Google Scholar
  • 7 Sundmacher R. Color atlas of herpetic eye disease. A practical guide to clinical management. Berlin Heidelberg: Springer-Verlag; 2009
    Google Scholar
  • 8 Wilhelmus K R. .Therapeutic interventions for herpes simplex virus epithelial keratitis [Review]. The Cochrane Collaboration. John Wiley and Sons, Ltd; 2009
    Google Scholar
  • 9 Stránská R, Schuurman R, Nienhuis E et al. Survey of aciclovir-resistant herpes simplex virus in the Netherlands: prevalence and characterization.  J Clin Virol. 2005;  32  7-18
    Google Scholar
  • 10 Iwayama S, Ono N, Ohmura Y et al. Antiherpesvirus activities of (1’S,2’R)-9-{[1’,2’-bis(hydroxymethyl)cycloprop-1’yl]methyl}guanine (A-5021) in cell culture.  Antimicrob Agents Chemother. 1998;  42 1666-1670
    Google Scholar
  • 11 Iwayama S, Ohmura Y, Suzuki K et al. Evaluation of anti-herpesvirus activity of (1’S,2’R)-9-{[1’,2’-bis(hydroxymethyl)cycloprop-1’yl]methyl}guanine (A-5021) in mice.  Antiviral Res. 1999;  42 139-148
    Google Scholar
  • 12 Itahashi M, Higaki S, Sugahara D et al. A-5021. A new Acyclovir analogue inhibits murine herpetic keratitis.  Cornea. 2008;  27 334-338
    Google Scholar
  • 13 Sozen E, Avunduk A M, Akyol N. Comparison of efficacy of oral valacyclovir and topical acyclovir in the treatment of herpes simplex keratitis: a randomized clinical trial.  Chemotherapy. 2006;  52 29-31
    Google Scholar
  • 14 Higaki S, Itahashi M, Deai T et al. Effect of oral valaciclovir on herpetic keratitis.  Cornea. 2006;  25 S64-S67
    Google Scholar
  • 15 Duan R, Vries R D, Osterhaus A DME et al. Acyclovir-resistant corneal HSV-1 isolates from patients with herpetic keratitis.  J Infect Dis. 2008;  198  659-663
    Google Scholar
  • 16 Bacon T H, Levin M J, Leary J J et al. Herpes simplex virus resistance to Acyclovir and Penciclovir after two decades of antiviral therapy.  Clin Microbiol Rev. 2003;  16 114-128
    Google Scholar
  • 17 Danve-Szatanek de C, Aymard M, Thouvenot D et al. Surveillance network for herpes simplex virus resistance to antiviral drugs: 3-year follow-up.  J Clin Microbiol. 2004;  42 242-249
    Google Scholar
  • 18 Power W J, Benedict-Smith A, Hillery M et al. Randomised double-blind trial of bromovinyldeoxyuridine (BVDU) and trifluorothymidine (TFT) in dendritic corneal ulceration.  Br J Ophthalmol. 1991;  75 649-651
    Google Scholar
  • 19 Behrens-Baumann W. Phosphonoformate (Foscarnet, PFA) versus Trifluorthymidine in the treatment of keratitis dendritica in the human. A double-blind, randomized, preliminary trial.  Acta Ophthalmol. 1992;  70 690-692
    Google Scholar
  • 20 Helgstrand E, Eriksson B, Johansson N G et al. Trisodium phosphonoformate, a new antiviral compound.  Science. 1978;  201 819-821
    Google Scholar
  • 21 Levin M J, Weinberg A, Leary J J et al. Development of Acyclovir-resistant herpes simplex virus early during the treatment of herpes neonatorum.  Pediatric Infect Dis J. 2001;  20 1094-1097
    Google Scholar
  • 22 Colin J. Ganciclovir ophthalmic gel, 0.15 %: a valuable tool for treating ocular herpes.  Clin Ophthalmol. 2007;  4 441-453
    Google Scholar
  • 23 Hoh H B, Hurley C, Claoue C et al. Randomised trial of gancoglivir and acyclovir in the treatment of herpes simplex dendritic keratitis: a multicentre study.  Br J Ophthalmol. 1996;  80 140-143
    Google Scholar
  • 24 Kaufman H E. Ganciclovir: a promising topical antiviral gel for herpetic keratitis.  Expert Rev Ophthalmol. 2009;  4 367-375
    Google Scholar
  • 25 Zhang J, Gao C, Wang L. Ocular pharmacokinetics and bioavailability of 0.2 % ganciclovir in-situ gelling eye drops.  Chin J Ophthalmol. 2006;  42 637-641
    Google Scholar
  • 26 Sundmacher R. Herpestherapie und -prophylaxe.  Klin Monatsbl Augenheilkd. 1976;  169 308-325
    Google Scholar
  • 27 Behrens-Baumann, W, Weber, U, Ansorg, R Trifluorthymidin und bakterielle Hornhautinfektion. Eine tierexperimentelle Studie. München; 1981: 291-294
    Google Scholar
  • 28 Behrens-Baumann W, Weber U, Ansorg R. Azyklovir und bakterielle Hornhautinfektion. Eine tierexperimentelle Studie.  Ber Dtsch Ophthalmol Ges. 1981;  78 399-401
    Google Scholar
  • 29 Yamaguchi K, Okumoto M, Stern G et al. Idoxuridine and bacterial corneal infection.  Am J Ophthalmol. 1979;  87 202-205
    Google Scholar
  • 30 Barron B A, Gee L, Hauck W W et al. Herpetic eye disease study.  Ophthalmology. 1994;  101 1871-1882
    Google Scholar
  • 31 Knickelbein J E, Hendricks R L, Charukamnoetkanok P. Management of herpes simplex virus stromal keratitis: an evidence-based review.  Surv Ophthalmol. 2009;  54 226-234
    Google Scholar
  • 32 Inoue Y. Immunological aspects of herpetic stromal keratitis.  Sem Ophthalmol. 2008;  23 221-227
    Google Scholar
  • 33 Wilhelmus K R. Diagnosis and management of herpes simplex stromal keratitis.  Cornea. 1987;  6 286-291
    Google Scholar
  • 34 Collum L MT, Logan P, Ravenscroft T. Acyclovir (Zovirax) in herpetic disciform keratitis.  Br J Ophthalmol. 1983;  67 115-118
    Google Scholar
  • 35 Wilhelmus K R, Gee L, Hauck W W et al. Herpetic eye disease study.  Ophthalmology. 1994;  101 1883-1896
    Google Scholar
  • 36 Behrens-Baumann W, Quentin C D, Vogel M. Acyclovir versus Trifluorthymidin in der Therapie der stromalen Herpes-Keratitis.  Klin Monatsbl Augenheilkd. 1986;  189 286-288
    Google Scholar
  • 37 Pleyer U, Mondino B J, Adamus S A et al. Immune response to Staphylococcus epidermidis endophthalmitis in a rabbit model.  Invest Ophthalmol Vis Sci. 1992;  33  2650-2663
    Google Scholar
  • 38 Kain H L. Prinzipien in der Behandlung der Endophthalmitis.  Klin Monatsbl Augenheilkd. 1997;  210 274-288
    Google Scholar
  • 39 Behrens-Baumann W, Paul H H, Ansorg R. Der Einfluss von Cortison bei der Behandlung der Pseudomonas-aeruginosa-Keratitis.  Klin Monatsbl Augenheilkd. 1981;  178 200-202
    Google Scholar
  • 40 Behrens-Baumann W, Küster M. Der Einfluss von Kortikosteroiden bei der antimykotischen Therapie der Candida-Keratitis.  Klin Monatsbl Augenheilkd. 1987;  191 222-225
    Google Scholar
  • 41 Schreiber W, Olbrisch A, Vorwerk C K et al. Combined topical fluconazole and corticosteroid treatment for experimental candida albicans keratomycosis.  Invest Ophthalmol Vis Sci. 2003;  44  2634-2643
    Google Scholar
  • 42 Behrens-Baumann W, Pleyer U. Therapie und Prognose der bakteriellen Keratitis.  Ophthalmologe. 2007;  104 15-20
    Google Scholar
  • 43 Behrens-Baumann W. Zur aktuellen Therapie der postoperativen Endophthalmitis.  Klin Monatsbl Augenheilkd. 2008;  225 919-923
    Google Scholar
  • 44 Behrens-Baumann W. Diagnostik und Therapie der Keratomykose.  Ophthalmologe. 2009;  106 471-481
    Google Scholar
  • 45 Gunduz K, Ozdemir O. Topical cyclosporin as an adjunct to topical acyclovir treatment in herpetic stromal keratitis.  Ophthalmic Res. 1997;  29 405-408
    Google Scholar
  • 46 Heiligenhaus A, Steuhl K P. Treatment of HSV-1 stromal keratitis with topical cyclosporin A: a pilot study.  Graefe’s Arch Clin Exp Ophthalmol. 1999;  237 435-438
    Google Scholar
  • 47 Rao S N. Treatment of herpes simplex Virus stromal keratitis unresponsive to topical prednisolone 1 % with topical cyclosporine 0.05 %.  Am J Ophthalmol. 2006;  141 771-772
    Google Scholar
  • 48 Heiligenhaus A, Bauer D, Meller D et al. Improvement of HSV-1 necrotizing keratitis with amniotic membrane transplantation.  Invest Ophthalmol Vis Sci. 2001;  42 1969-1974
    Google Scholar
  • 49 Heiligenhaus A, Li H, Hernandez G alindo E E et al. Management of acute ulcerative and necrotising herpes simplex and zoster keratitis with amniotic membrane transplantation.  Br J Ophthalmol. 2003;  87 1215-1219
    Google Scholar
  • 50 Shi W, Chen M, Xie L. Amniotic membrane transplantation combined with antiviral and steroid therapy for herpes necrotizing stromal keratitis.  Ophthalmology. 2007;  114 1476-1481
    Google Scholar
  • 51 Saravia M, Zapata G, Ferraiolo P et al. Anti-VEGF monoclonal antibody-induced regression of corneal neovascularization and inflammation in a rabbit model of herpetic stromal keratitis.  Graefe’s Arch Clin Exp Ophthalmol. 2009;  247 1409-1416
    Google Scholar
  • 52 Barney N P, Foster C S. A prospective randomized trial of oral acyclovir after penetrating keratoplasty for herpes simplex keratitis.  Cornea. 1994;  13 232-236
    Google Scholar
  • 53 Simon A L, Pavan-Langston D. Long-term oral aciclovir therapy. Effect on recurrent infectious herpes simplex keratitis in patients with and without grafts.  Ophthalmology. 1996;  103 1399-1405
    Google Scholar
  • 54 Rooij van J, Rijneveld W J, Remeijer L J et al. A retrospective study on the effectiveness of oral acyclovir to prevent herpes simplex recurrence in corneal grafts.  Eur J Ophthalmol. 1995;  4  214-218
    Google Scholar
  • 55 Rooij van J, Rijneveld W J, Remeijer L et al. Effect of oral acyclovir after penetrating keratoplasty for herpetic keratitis. A placebo-controlled multicenter trial.  Ophthalmology. 2003;  110 1916-1919
    Google Scholar
  • 56 Herpetic Eye Disease Study Group (HEDS) . Acyclovir for the prevention of recurrent herpes simplex virus eye disease.  N Engl J Med. 1998;  339 300-306
    Google Scholar
  • 57 Uchoa U BC, Rezende R A, Carrasco M A et al. Long-term acyclovir use to prevent recurrent ocular herpes simplex virus infection.  Arch Ophthalmol. 2003;  121 1702-1704
    Google Scholar
  • 58 Miserocchi E, Modorati G, Galli L et al. Efficacy of Valacyclovir vs Acyclovir for the prevention of recurrent herpes simplex virus eye disease: a pilot study.  Am J Ophthalmol. 2007;  144 547-551
    Google Scholar
  • 59 Schwartz G S, Holland E J. Oral acyclovir for the management of herpes simplex virus keratitis in children.  Ophthalmology. 2000;  107 278-282
    Google Scholar
  • 60 Duan R, Vries R D, Dun van J M et al. Acyclovir susceptibility and genetic characteristics of sequential herpes simplex virus type 1 corneal isolates from patients with recurrent herpetic keratitis.  J Infect Dis. 2009;  200  1402-1414
    Google Scholar
  • 61 Kaye de S, Choudhary A. Herpes simplex keratitis.  Progr Ret Eye Res. 2006;  25 355-380
    Google Scholar
  • 62 Tambasco F P, Cohen E J, Nguyen L H et al. Oral acyclovir after penetrating keratoplasty for herpes simplex keratitis.  Arch Ophthalmol. 1999;  117 445-449
    Google Scholar
  • 63 Foster C S, Duncan J. Penetrating keratoplasty for herpes simplex keratitis.  Am J Ophthalmol. 1981;  92 336-343
    Google Scholar
  • 64 Moyes A L, Sugar A, Musch D C et al. Antiviral therapy after penetrating keratoplasty for herpes simplex keratitis.  Arch Ophthalmol. 1994;  112 601-607
    Google Scholar
  • 65 Kaufman H E. Epithelial erosion syndrome: metaherpetic keratitis.  Am J Ophthalmol. 1964;  57 983-987
    Google Scholar
  • 66 Kaufman H E. Treatment of oral diseases of the cornea and external eye.  Progr Ret Eye Res. 2000;  19 69-85
    Google Scholar

Prof. Dr. Wolfgang Behrens-Baumann

Universitäts-Augenklinik, Otto-von-Guericke-Universität Magdeburg

Leipziger Str. 44

39120 Magdeburg

Phone: ++ 49/3 91/6 71 35 71

Fax: ++ 49/3 91/6 71 35 70

Email: augenklinik@ovgu.de