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DOI: 10.1055/s-0029-1244057
© Georg Thieme Verlag KG Stuttgart · New York
Reaktive neutrophile Dermatosen
Reactive Neutrophilic DermatosisPublication History
Publication Date:
24 March 2010 (online)
![](https://www.thieme-connect.de/media/derma/201005/lookinside/thumbnails/10.1055-s-0029-1244057-1.jpg)
Zusammenfassung
Reaktive neutrophile Dermatosen wie das Pyoderma gangraenosum und die akute febrile neutrophile Dermatose (Sweet-Syndrom) zeigen bei unterschiedlichen klinischen Erscheinungsbildern ähnliche pathologische Merkmale der Entzündung am Hautorgan. Histopathologisch finden sich Infiltrate von normalen polymorphkernigen Leukozyten, eine erhöhte Anzahl von Granulozyten im peripheren Blut und die häufige Assoziation mit systemischen Erkrankungen. Am häufigsten handelt es sich dabei um chronische gastrointestinale, rheumatologische oder hämatologische Erkrankungen, die sich zum Zeitpunkt der Hauterscheinungen in einer akuten Phase oder Krankheitverschlechterung befinden. Die genauen pathopysiologischen Bedingungen zur Ausprägung einer reaktiven neutrophilen Dermatose sind nicht bekannt, jedoch ist die Therapie mit systemischen antientzündlichen Medikamenten und insbesondere durch die anti-TNFα-Antikörper-Behandlung in den meisten Fällen effektiv.
Abstract
Reactive neutrophilic dermatoses like pyoderma gangrenosum or Sweet's syndrome describe distinct entities associated by similar pathologic characteristics. Histologic examination reveals a dense epidermal and/or dermal inflammatory infiltrate composed of neutrophils. Typically, there is also an increased amount of neutrophiles in the peripheral blood and sometimes association with systemic inflammatory diseases. Common associated conditions are chronic inflammatory bowel disease, autoimmune and collagen vascular diseases and hematologic malignancies. Time of manifestation is often associated with exacerbation of the underlying disease. The exact pathogenesis of reactive neutrophilic dermatoses is still unknown, but these disorders typically respond to antiinflammatory therapies, especially to anti-TNF-α based therapeutic approaches.
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Prof. Dr. Edgar Dippel
Hautklinik
Klinikum der Stadt Ludwigshafen GmbH
Bremserstr. 79
67063 Ludwigshafen
Email: dippele@klilu.de