Flavonol Glycoside Gallate and Ferulate Esters from Persicaria lapathifolia as Inhibitors of Superoxide Production in Human Monocytes Stimulated by Unopsonized Zymosan

Abstract

Aerial parts of Persicaria lapathifolia S.F. Gray (Polygonaceae) exhibited an inhibitory effect on superoxide production in unopsonized zymosan-stimulated human monocytes. Two known compounds, quercetin 3-O-β-(2″-galloyl)-glucopyranoside and quercetin 3-O-β-(2″-galloyl)-rhamnopyranoside, and a new compound, quercetin 3-O-β-(6″-feruloyl)-galactopyranoside, were isolated as the inhibitors of superoxide production by activity-guided fractionation. IC₅₀ values were shown at the concentrations of 2.1µM by quercetin 3-O-β-(2″-galloyl)-glucopyranoside, 1.9µM by quercetin 3-O-β-(2″-galloyl)-rhamnoypranoside, and 3.5µM by quercetin 3-O-β-(6″-feruloyl)-galactopyranoside whose inhibitory potencies were similar to oxyphenylbutazone (IC₅₀ = 1.9µM) as a positive control.

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