Progesterone Function in Human Endometrium: Clinical Perspectives

Steven L Young; Bruce A Lessey

doi:10.1055/s-0029-1242988

Seminars in Reproductive Medicine, Inhaltsverzeichnis

Semin Reprod Med 2010; 28(1): 005-016
DOI: 10.1055/s-0029-1242988

Progesterone Function in Human Endometrium: Clinical Perspectives

Steven L. Young¹ , Bruce A. Lessey²

¹Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, University of North Carolina, Chapel Hill, North Carolina
²Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, University Medical Group, Greenville Hospital System, Greenville, South Carolina

Abstract

ABSTRACT

Progesterone is essential for endometrial receptivity and successful establishment of pregnancy. Either an insufficient progesterone concentration or an insufficient response to progesterone, therefore can lead to infertility and pregnancy loss. Assessment of the role that either progesterone insufficiency or inadequate progesterone response plays in human reproductive failure has been difficult to assess because serum progesterone concentrations fluctuate markedly, limiting the ability to characterize sufficiency of progesterone, and there are no highly reliable markers of endometrial function available. Recent evidence demonstrates exquisite sensitivity of normal endometrium to very low levels of progesterone stimulation, suggesting that progesterone insufficiency should not be a common cause of reproductive failure. Further evidence suggests that women with endometriosis, and possibly polycystic ovarian syndrome, have an altered progesterone response, which may explain some of the clinical features of these disorders and supports the hypothesis that progesterone resistance underlies some cases of human reproductive failure.

KEYWORDS

Luteal phase defect - progesterone resistance - endometrium - embryo implantation - endometriosis

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Referenzen

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Steven L YoungM.D. Ph.D.

Department of Obstetrics & Gynecology (CB# 7570)

4005 Old Clinic Bldg, University of North Carolina at Chapel Hill, Chapel Hill NC 27599-7570

eMail: youngs@med.unc.edu